Prognostic significance of epidermal growth factor receptor gene mutations and human epidermal growth factor 2 expression in breast carcinoma metastatic to the liver

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAKATLI, AYSE NUR/0000-0002-9677-2456
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidAKATLI, AYSE NUR/ABH-4455-2020
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.contributor.authorYilmaz, Tugba Biri
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorSamdanci, Emine
dc.contributor.authorSoylu, Nese Karadag
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorAkpolat, Nusret
dc.date.accessioned2024-08-04T21:00:55Z
dc.date.available2024-08-04T21:00:55Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Breast cancer is the most prevalent cancer among females, and metastatic disease is not curable and is treated palliatively. Members of the ErbB family have an important role in the development and progression of breast cancer. The aim of this study was to determine the relationship between epidermal growth factor receptor (EGFR) gene mutation, human epidermal growth factor 2 (HER2) expression, hormone receptor statuses, and clinicopathological parameters in liver metastases from breast cancer. Materials and Methods: This study included 41 patients diagnosed with liver metastasis from breast carcinoma, based on morphological and immunohistochemical findings, in our pathology laboratory between 2011 and 2018. EGFR gene mutations were analyzed by polymerase chain reaction (PCR) in these cases. Results: EGFR gene mutation analysis was performed by PCR, and no mutations were detected. HER2 and ER statuses of the primary breast tumor were available in 23 cases. HER2 status conversions were present in 9 cases (39.1%); however, this was not statistically significant (P = 0.197). Estrogen receptor (ER) conversions were present in 4 cases (17.4%); however, this was not statistically significant (P = 1.000). Progesterone receptor (PR) conversions were detected in 10 cases (45.5%). There were 10 (45.5%) cases with PR-positive primary tumors and PR-negative liver metastases. No cases with a PR-negative primary tumor developed a PR-positive liver metastasis (P = 0.02). Conclusions: No EGFR gene mutations were detected in any of our cases by PCR. There was no statistically significant relationship between clinicopathological parameters and EGFR mutation. The comparison of ER, PR, and HER2 expression between the primary tumor and metastases revealed status conversions in some cases. However, only PR conversion was statistically significant. Studies on EGFR gene mutations that include larger series are warranted to identify the candidates who can benefit from targeted therapies.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit (BAP)en_US
dc.description.sponsorshipThis study was financially supported by Inonu University Scientific Research Projects Coordination Unit (BAP).en_US
dc.identifier.doi10.4103/ccij.ccij_70_19
dc.identifier.endpage253en_US
dc.identifier.issn2278-0513
dc.identifier.issue6en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.4103/ccij.ccij_70_19
dc.identifier.urihttps://hdl.handle.net/11616/103928
dc.identifier.volume8en_US
dc.identifier.wosWOS:000505773500007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMiddle Eastern Assoc Cancer Researchen_US
dc.relation.ispartofClinical Cancer Investigation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast carcinomaen_US
dc.subjectepidermal growth factor receptoren_US
dc.subjecthormone receptorsen_US
dc.subjecthuman epidermal growth factor 2en_US
dc.subjectliver metastasisen_US
dc.titlePrognostic significance of epidermal growth factor receptor gene mutations and human epidermal growth factor 2 expression in breast carcinoma metastatic to the liveren_US
dc.typeArticleen_US

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