Molecular Mechanism of the Protective Effect of Tianeptine Against Ketamine-Induced Cardiac Injury in Rats

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dc.authoridTaş, Hakan Gökalp/0000-0001-5680-9544;
dc.authorwosidTaş, Hakan Gökalp/HHD-2030-2022
dc.authorwosidUğur, Kerim/AAK-5379-2021
dc.contributor.authorYildiz, Sevier
dc.contributor.authorUgur, Kerim
dc.contributor.authorTas, Hakan G.
dc.contributor.authorOzcicek, Fatih
dc.contributor.authorKuyrukluyildiz, Ufuk
dc.contributor.authorMendil, Ali S.
dc.contributor.authorCankaya, Murat
dc.date.accessioned2024-08-04T21:00:01Z
dc.date.available2024-08-04T21:00:01Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractKetamine is a short-acting anesthetic drug that is derived from phencyclidine. Ketamine is used to treat depression and chronic pain disorders, as well as for anesthesia, analgesia, and sedation. Ketamine's sympathomimetic characteristic causes cardiotoxicity. The pathophysiology of ketamine's harmful impact has been linked to reactive oxygen species (ROS) and proinflammatory cytokines such as interleukin 1 beta (IL-1), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). Tianeptine is an antidepressant that works similarly to tricyclic antidepressants. According to studies, tianeptine reduces the production of proinflammatory cytokines such as ROS, IL-1, IL-6, and TNF-alpha. Tianeptine has a sympatholytic action as well. All of this evidence suggests that tianeptine might help to reduce ketamine cardiotoxicity. The goal of our research is to use biochemical and histological techniques to see how tianeptine affects ketamine-induced cardiotoxicity in rats.en_US
dc.identifier.endpage2926en_US
dc.identifier.issn0326-2383
dc.identifier.issue12en_US
dc.identifier.startpage2920en_US
dc.identifier.urihttps://hdl.handle.net/11616/103712
dc.identifier.volume40en_US
dc.identifier.wosWOS:000791171400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcardiotoxicityen_US
dc.subjectketamineen_US
dc.subjecttianeptineen_US
dc.titleMolecular Mechanism of the Protective Effect of Tianeptine Against Ketamine-Induced Cardiac Injury in Ratsen_US
dc.typeArticleen_US

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