Comparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients withdifferent grades of knee osteoarthritis

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dc.contributor.authorBuyukavci, Raikan
dc.contributor.authorAkturk, Semra
dc.contributor.authorSag, Sinem
dc.date.accessioned2019-07-09T06:45:46Z
dc.date.available2019-07-09T06:45:46Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to compare platelet distribution width (PDW) and neutrophil to lymphocyte ratio (NLR) values in mild-to-moderate and severe knee osteoarthritis (OA). METHODS: This was a retrospective study of patients with knee OA according to the Kellgren-Lawrence (KL) grading system. Of 465 patients, 231 were excluded (62 due to not meeting the inclusion criteria and 169 due to the lack of simultaneous haemogram and radiographic evaluations). Demographic characteristics and PDW and NLR values were recorded. The patients were then divided into two groups: KL grade 1-3 (mild-to-moderate OA) and KL grade 4 (severe OA). RESULTS: In severe knee OA patients, blood PDW (13.44 +/- 2.58, p = 0.01) and NLR values (2.16 +/- 0.84, p = 0.04) were elevated as compared with those in mild-to-moderate knee OA patients. Blood PDW and NLR values of >= 12.5 and >= 2.1, respectively, were taken as cut-offs based on a receiver operating characteristics (ROC) curve analysis. In the ROC curve analysis, blood NLR >= 2.1 had 60% sensitivity and 64.8% specificity, and PDW >= 12.5 had 61% sensitivity and 58% specificity in predicting severe knee OA. In a univariate analysis, age (p < 0.001), PDW >= 12.5 (p = 0.029) and blood NLR >= 2.1 (p = 0.030) emerged as significant predictors of the severe knee OA. CONCLUSION: The results suggested that the blood PDW and NLR are novel inflammatory markers that can predict the radiographic severity of knee OA in clinical practice.en_US
dc.identifier.citationBuyukavci, R .Akturk, S. Sag, S . (2018). Comparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients withdifferent grades of knee osteoarthritis. Cilt:31. Sayı:6. 1035-1039 ss.en_US
dc.identifier.doi10.3233/BMR-171028en_US
dc.identifier.endpage1039en_US
dc.identifier.issue6en_US
dc.identifier.startpage1035en_US
dc.identifier.urihttps://hdl.handle.net/11616/12430
dc.identifier.volume31en_US
dc.language.isoenen_US
dc.publisherIos press, nıeuwe hemweg 6b, 1013 bg amsterdam, netherlandsen_US
dc.relation.ispartofJournal of back and musculoskeletal rehabılıtatıonen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectPhysıcal functıonen_US
dc.subjectbıomarkersen_US
dc.subjectpredıctoren_US
dc.subjectolderen_US
dc.subjectınterleukın-6en_US
dc.subjectmarkeren_US
dc.subjectadultsen_US
dc.subjectvolumeen_US
dc.subjectpaınen_US
dc.titleComparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients withdifferent grades of knee osteoarthritisen_US
dc.typeArticleen_US

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