The Beneficial Effects of Resveratrol on Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6J Mouse Model

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dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorTecellioglu, M.
dc.contributor.authorTurkmen, N. Basak
dc.contributor.authorCiftci, O.
dc.contributor.authorTaslidere, A.
dc.contributor.authorEkmekyapar, T.
dc.contributor.authorYuce, H.
dc.contributor.authorOztanir, M. N.
dc.date.accessioned2024-08-04T21:01:19Z
dc.date.available2024-08-04T21:01:19Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMultiple sclerosis (MS) is a disease of the central nervous system of unknown cause and limited therapeutical treatments. In this study we analyzed the effects of resveratrol (RSV), a polyphenolic compound with well-known neuroprotective effects, on neuronal damage in brain tissue caused by experimental autoimmune encephalomyelitis (EAE)-an established model of multiple sclerosis, using C57BL/6J female mice. A total of 40 C57BL/6J female mice were divided equally into four groups: control, EAE, RSV and RSV + EAE. 14 days after induction of EAE with myelin oligodendrocyte glycoprotein MOG35-55 and pertussis toxin, mice were treated via oral gavage with RSV at the doses of 20 mg/kg per day for 7 days. According to our results RSV treatment prevented oxidative stress caused by EAE via a decrease in lipid peroxidation and an increase in the elements of the antioxidant defense systems in brain tissue. The histopathological changes in caspase-3 and IL-17 activity and cytokine levels (TNF-alpha and IL-1 beta) induced by EAE in mouse brain tissue were reversed by RSV treatment. Moreover, elevated TNF-alpha and IL-1 beta levels, induced by EAE, were diminished in blood serum, and neurological deficits were reversed in EAE mice treated with RSV. Our findings suggest that RSV treatment effectively prevents oxidative, immunological, and histological changes in the brain caused by EAE and the beneficial effects of RSV are likely to result from its strong antioxidant and anti-inflammatory properties.en_US
dc.identifier.doi10.1134/S0022093022040093
dc.identifier.endpage1054en_US
dc.identifier.issn0022-0930
dc.identifier.issn1608-3202
dc.identifier.issue4en_US
dc.identifier.startpage1041en_US
dc.identifier.urihttps://doi.org/10.1134/S0022093022040093
dc.identifier.urihttps://hdl.handle.net/11616/104289
dc.identifier.volume58en_US
dc.identifier.wosWOS:000846813900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofJournal of Evolutionary Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmultiple sclerosisen_US
dc.subjectpertussis toxinen_US
dc.subjectoxidative damageen_US
dc.subjectTNF-alphaen_US
dc.subjectresveratrolen_US
dc.titleThe Beneficial Effects of Resveratrol on Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6J Mouse Modelen_US
dc.typeArticleen_US

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