Urine Xanthine Oxidase and Myeloperoxidase Activity in Pediatric Urinary Tract Infections

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dc.authoridKurutas, Ergul Belge/0000-0002-6653-4801
dc.authorwosidKurutas, Ergul Belge/CAJ-2682-2022
dc.contributor.authorDavutoglu, Mehmet
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorKurutas, Ergul Belge
dc.contributor.authorOlgar, Seref
dc.contributor.authorGuler, Ekrem
dc.contributor.authorAtli, Yalcin
dc.date.accessioned2024-08-04T21:02:20Z
dc.date.available2024-08-04T21:02:20Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the relationships between urinary tract infection (UTI), and activity of antioxidant enzymes, xanthine oxidase (XO) and myeloperoxidase (MPO) in urine of children with UTI Design: Prospective observational study Setting: Department of Pediatrics, Kahramanmaras Sutcu Imam University Faculty of Medicine, Turkey Subjects and Methods: A total of 115 random children admitted to our hospital for urinary symptoms, 61 girls and 54 boys, aged between 2 and 15 years (average 10 years) were included. Study subjects were divided into four groups: Group 1 consisted of 29 pyuria positive and urine culture negative children; Group 2 included 30 children with pyuria and positive urine culture; Group 3 included 26 pyuria negative and urine culture positive children and Group 4 included 30 with pyuria and negative urine culture. Measurement of urine XO and MPO activity were performed spectrophotometrically. Intervension: Urine samples Main Outcome Measures: Antioxidant enzyme activity levels in urine were examined in children with urinary tract infection. Results: Urinary XO activities in Group 2 were significantly higher compared with other groups (p < 0.001, p = 0.001 and p < 0.001, respectively). Significantly different MPO activities were found between Group 1 and Group 2 (p = 0.007). However, no significant difference was found between Group 3 and 4. Conclusion: Significantly increased MPO and XO enzyme activity was found in children with UTI. Measurement of MPO and XO activity may be useful in children with urinary symptoms to diagnose UTI, before obtaining a positive urine culture.en_US
dc.identifier.endpage202en_US
dc.identifier.issn0023-5776
dc.identifier.issue3en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://hdl.handle.net/11616/104686
dc.identifier.volume45en_US
dc.identifier.wosWOS:000323463000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecturine myeloperoxidaseen_US
dc.subjecturinary tract infectionen_US
dc.subjecturine xanthine oxidaseen_US
dc.titleUrine Xanthine Oxidase and Myeloperoxidase Activity in Pediatric Urinary Tract Infectionsen_US
dc.typeArticleen_US

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