Drug induced autoimmune hepatitis: a single center experience.

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dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridYildirim, Oguzhan/0000-0001-8254-0104
dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridharputluoglu, hakan/0000-0001-8537-5941
dc.authoridbilgic, yılmaz/0000-0002-2169-5548
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidharputluoglu, hakan/ABI-6451-2020
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.contributor.authorBilgic, Yilmaz
dc.contributor.authorHarputluoglu, Hakan
dc.contributor.authorYilmaz, Cengiz
dc.contributor.authorKaradag, Nese
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSeckin, Yuksel
dc.date.accessioned2024-08-04T20:57:43Z
dc.date.available2024-08-04T20:57:43Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Many drugs such as minocycline, nitrofurantoin, halothane, non-steroidal anti-inflammatory drugs, anti TNF (Tumor Necrosis Factor) antagonists can induce the autoimmune hepatitis. Herein, we aimed to assess patients suffering from drug induced autoimmune hepatitis who were hospitalized with acute hepatitis like transaminase elevations to our clinic between 2009-2015. Method: The patients were determined using simplified diagnostic criteria of the International Autoimmune Hepatitis Group. Results: We determined 9 patients whose score were compatible with the diagnosis of Autoimmune hepatitis (AIH). Three patients were older than 50, and six patients were between 19 and 31. Seven of nine patients were female. The drugs thought responsible for AIH were as follows; ciprofloxacin alone, amoxicillin plus nimesulid, amoxicillin plus ornidazole, amoxicillin alone, a combined oral contraceptive pill plus a mixture of natural drugs, metronidazole plus dexketoprofen, ramipril plus metronidazole, levofloxacin alone and venlafaxine plus mianserin for each case. Five of nine patients had been followed up conservatively upon discontinuation of drug(s) and did not need any treatment during hospitalization and resolved spontaneously. Four patients received immunosuppressive treatment which was withdrawn in 3 of those 4 patients after 3 to 6 months upon remission without relapse. Conclusion: Drug induced autoimmune hepatitis (DIAIH) can be presented with acute hepatitis of unknown etiology. Female sex seems to be a risk factor for DIAH. Treatment decisions should be given according to patient's clinical status and follow up at acute presentations. There can be no treatment need, but, when needed generally a short course of immunosuppressive treatment can be sufficient.en_US
dc.identifier.endpage6532en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue15en_US
dc.identifier.startpage6528en_US
dc.identifier.urihttps://hdl.handle.net/11616/102872
dc.identifier.volume28en_US
dc.identifier.wosWOS:000412521200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrugen_US
dc.subjectAutoimmunityen_US
dc.subjectHepatitisen_US
dc.titleDrug induced autoimmune hepatitis: a single center experience.en_US
dc.typeArticleen_US

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