The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid

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dc.authoridYAGMURCA, MURAT/0000-0001-9774-8151
dc.authoridUçar, Muharrem/0000-0002-1232-9829;
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidYAGMURCA, MURAT/A-1851-2018
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidOzturk, Feral/A-2678-2016
dc.contributor.authorYagmurca, Murat
dc.contributor.authorUcar, Muharrem
dc.contributor.authorFadillioglu, Ersin
dc.contributor.authorErdogan, Hasan
dc.contributor.authorOzturk, Feral
dc.date.accessioned2024-08-04T21:02:02Z
dc.date.available2024-08-04T21:02:02Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world. causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by N omega-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA. Materials and Methods: Male Sprague-Dawley rats were divided into seven groups: control, ASA, ASA+L-NAME, ASA+L-Arg, ASA+L-Arg+L-NAME, only L-NAME. and only L-Arg groups. After administration of the drugs, the rats were decapitated and their stomachs were removed and fixed in 10% neutral-buffered formalin solution. Results: Mucosal erosion, intramucosal hemorrhage, inflammatory cell infiltration, gland cell detachment, and necrosis were observed in the ASA group. It was demonstrated that L-Arg administration decreased the gastric mucosal injury, whereas L-NAME administration increased the extent and severity of the gastric injury induced by ASA. L-Arg or L-NAME administration alone did not affect gastric mucosa. Conclusions: We concluded that NO may have protective effects on gastric mucosal injury induced by ASA.en_US
dc.description.sponsorshipInonu University [2001/53]en_US
dc.description.sponsorshipThis study was supported by a grant from Inonu University (2001/53).en_US
dc.identifier.doi10.3906/sag-0712-22
dc.identifier.endpage19en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0712-22
dc.identifier.urihttps://hdl.handle.net/11616/104411
dc.identifier.volume39en_US
dc.identifier.wosWOS:000264805800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitric oxideen_US
dc.subjectstomach injuryen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectmicroscopyen_US
dc.titleThe Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Aciden_US
dc.typeArticleen_US

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