Protective Effect of Pomegranate Juice on Lead Acetate-Induced Liver Toxicity in Male Rats

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dc.authoridAydin, Ali/0000-0002-9550-9111
dc.authoridBulmus, Ozgur/0000-0001-7736-402X
dc.authoridaydin, merve/0000-0001-6221-4424
dc.authorwosidAydin, Ali/ACM-7774-2022
dc.contributor.authorPekmez, Hidir
dc.contributor.authorAnnac, Ebru
dc.contributor.authorBulmus, Ozgur
dc.contributor.authorZencirci, Buesra
dc.contributor.authorAydin, Merve
dc.contributor.authorAydin, Ali
dc.date.accessioned2024-08-04T21:00:55Z
dc.date.available2024-08-04T21:00:55Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In this study, the harmful effects of lead acetate on rat liver tissue and the efficacy of pomegranate juice against these effects were investigated. Methods: 28 male Wistar albino rats were divided into four groups: control, lead acetate (50 mL/ kg), pomegranate juice (1 mL/kg), and lead acetate + pomegranate juice (50 mL/kg+1 mL/kg). Lead acetate and pomegranate juice were administered orally. Results: When compared with the control group, it was seen that the lead acetate had an increase in the malondialdehyde level and a decrease in reduced Glutathione, Glutathione S-transferase, and Carboxylesterases. Group lead acetate + pomegranate juice had a reduction in malondialdehyde level and an increase in Glutathione, Glutathione S-transferase, and Carboxylesterases compared with the group lead acetate. The lead level of group lead acetate + pomegranate juice decreased compared to the group lead acetate. Cellular degeneration and irregular hepatic cords were observed in group lead acetate's liver tissue, and the negative changes were lost in group lead acetate + pomegranate juice. Conclusion: It was observed that pomegranate juice had a protective effect against liver toxicity caused by lead acetate.en_US
dc.identifier.doi10.58600/eurjther1927
dc.identifier.endpage169en_US
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue2en_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://doi.org/10.58600/eurjther1927
dc.identifier.urihttps://hdl.handle.net/11616/103940
dc.identifier.volume30en_US
dc.identifier.wosWOS:001153647200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherPera Yayincilik Hizmetlerien_US
dc.relation.ispartofEuropean Journal of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectLead acetateen_US
dc.subjectLiveren_US
dc.subjectPomegranate juiceen_US
dc.subjectOxidative stressen_US
dc.titleProtective Effect of Pomegranate Juice on Lead Acetate-Induced Liver Toxicity in Male Ratsen_US
dc.typeArticleen_US

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