Is There a Relationship Between Vitamin D Deficiency and Primary Monosymptomatic Enuresis Nocturna?

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dc.contributor.authorGulyuz, Abdulgani
dc.date.accessioned2026-04-04T13:31:10Z
dc.date.available2026-04-04T13:31:10Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: The aim of this study was to investigate the relationship between primary monosymptomatic enuresis nocturna (PMNE) and vitamin D deficiency in children. Patients and Methods: This retrospective case-control study included 307 PMNE patients aged 5-18 years and 254 age- and sex-matched healthy control subjects. Demographic data and biochemical parameters of the participants were obtained from hospital records. Serum 25(OH)D3 levels were measured using the chemiluminescence immunoassay method. The Mann-Whitney U test, Chi-square test, Pearson correlation and multivariate logistic regression analysis were used for statistical analyses. Results: Serum 25(OH)D3 levels were significantly lower in the PMNE group compared to the control group (p < 0.001). The rate of vitamin D deficiency was higher in the PMNE group. Vitamin D deficiency (OR: 3.164, 95% CI: 1.195-8.378, p = 0.02) and family history of enuresis (OR: 2.790, 95% CI: 1.01-5.8, p = 0.04) were found to be independent associated factors for PMNE. A significant negative correlation was found between serum vitamin D level and weekly bedwetting frequency (r = -0.377, p < 0.001). Conclusions: Serum 25(OH)D3 levels were significantly lower in the PMNE group (p < 0.001, Cohen's d = 0.89). It is recommended that vitamin D levels should be routinely evaluated in children with PMNE and the potential benefits of vitamin D supplementation should be investigated in prospective studies.
dc.identifier.doi10.3390/diagnostics15111345
dc.identifier.issn2075-4418
dc.identifier.issue11
dc.identifier.orcid0000-0001-5797-9115
dc.identifier.pmid40506917
dc.identifier.urihttps://doi.org/10.3390/diagnostics15111345
dc.identifier.urihttps://hdl.handle.net/11616/108618
dc.identifier.volume15
dc.identifier.wosWOS:001506553400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorGulyuz, Abdulgani
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofDiagnostics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectprimary monosymptomatic enuresis nocturna
dc.subjectvitamin D deficiency
dc.subjectchild
dc.subjectassociated factors
dc.subjectbedwetting
dc.titleIs There a Relationship Between Vitamin D Deficiency and Primary Monosymptomatic Enuresis Nocturna?
dc.typeArticle

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