Histopathological examination of explanted liver after transplantation in patients with cryptogenic cirrhosis

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dc.authorid109262en_US
dc.contributor.authorTardu, Ali
dc.contributor.authorKaragül, Servet
dc.contributor.authorYağcı, Mehmet Ali
dc.contributor.authorErtuğrul, İsmail
dc.contributor.authorSümer, Fatih
dc.contributor.authorKırmızı, Serdar
dc.contributor.authorYaylak, Faik
dc.contributor.authorKoç, Cemalettin
dc.contributor.authorHatipoğlu, Hamit Sinan
dc.contributor.authorKayaalp, Cüneyt
dc.contributor.authorYılmaz, Sezai
dc.date.accessioned2017-09-12T11:44:04Z
dc.date.available2017-09-12T11:44:04Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. Cryptogenic cirrhosis is a common indication for liver transplantation. Diagnosis is made after exclusion of other causes of cirrhosis. In this study, the aim was to evaluate patients with cryptogenic cirrhosis after histopathological examination of explanted liver. Materials and Methods. A retrospective histopathological chart review of 117 patients with cryptogenic cirrhosis who had liver transplantation between November 2009 and June 2014 was performed. Age, sex, operative features, survival rates, and preoperative and postoperative diagnosis were evaluated. Results. During the study period, 123 liver transplantations were performed for these 117 patients. Deceased donor liver transplantations were performed in 23 (18.7%) of the cases. Retransplantations were performed in 5 patients. Median age was 48 years, and female-tomale ratio was 41:76. Hepatosteatosis were observed in 29 patients. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis were observed in 20 (12%) and 9 (7.7%) of these patients, respectively. Autoimmune hepatitis was observed in 2 patients. The definitive cause of cirrhosis was unclear in 68 (58%) of the patients. Incidental malignant and premalignant lesions were observed in 15 patients. Conclusions. Histopathological examination of the explanted liver after liver transplantation in those patients with cryptogenic cirrhosis may significantly help to diagnose the cause of cirrhosis, such as nonalcoholic steatohepatitis or autoimmune hepatitis, with using the scoring system developed by the International Autoimmune Hepatitis Workgroup. In addition, incidental malignant or premalignant lesions may be observed.en_US
dc.identifier.citationTardu, A. Karagül, S. Yağcı, M. A. Ertuğrul, İ. Sümer, F. Kırmızı, S. Yaylak, F. Koç, C. Hatipoğlu, H. S. Kayaalp, C. Yılmaz, S. (2015). Histopathological examination of explanted liver after transplantation in patients with cryptogenic cirrhosis. Transplantation Proceedings. 47(5):1450-1452.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.020.en_US
dc.identifier.endpage1452en_US
dc.identifier.issue5en_US
dc.identifier.startpage1450en_US
dc.identifier.urihttps://hdl.handle.net/11616/7758
dc.identifier.volume47en_US
dc.language.isoenen_US
dc.publisherTransplantation Proceedingsen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleHistopathological examination of explanted liver after transplantation in patients with cryptogenic cirrhosisen_US
dc.typeArticleen_US

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