Efficacy of serum apelin and galectin-3 as potential predictors of mortality in severe COVID-19 patients

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dc.authoridOtlu, Onder/0000-0001-5958-7609
dc.authoridIN, ERDAL/0000-0002-8807-5853
dc.authorwosidOtlu, Onder/W-3887-2018
dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorGeckil, Aysegul Altintop
dc.contributor.authorAltan, Nazife Ozge
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorOtlu, Onder
dc.contributor.authorErdem, Mehmet
dc.contributor.authorIn, Erdal
dc.date.accessioned2024-08-04T20:58:38Z
dc.date.available2024-08-04T20:58:38Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractApelin is a cardioprotective biomarker while galectin-3 is a pro-inflammatory and profibrotic biomarker. Endothelial dysfunction, hyperinflammation, and pulmonary fibrosis are key mechanisms that contribute to the development of adverse outcomes in Coronavirus disease 2019 (COVID-19) infection. This study aims to analyze the prognostic value of serum apelin and galectin-3 levels to early predict patients at high risk of mortality in patients hospitalized for severe COVID-19 pneumonia. The study included 78 severe COVID-19 patients and 40 healthy controls. The COVID-19 patients were divided into two groups, survivors and nonsurvivors, according to their in-hospital mortality status. Basic demographic and clinical data of all patients were collected, and blood samples were taken before treatment. In our study, serum apelin levels were determined to be significantly lower in both nonsurvivor and survivor COVID-19 patients compared to the control subjects (for both groups, p < 0.001). However, serum apelin levels were similar in survivor and nonsurvivor COVID-19 patients (p > 0.05). Serum galectin-3 levels were determined to be higher in a statistically significant way in nonsurvivors compared to survivors and controls (for both groups; p < 0.001). Additionally, serum galectin-3 levels were significantly higher in the survivor patients compared to the control subjects (p < 0.001). Positive correlations were observed between galectin-3 and age, ferritin, CK-MB and NT-proBNP variables (r = 0.32, p = 0.004; r = 0.24, p = 0.04; r = 0.24, p = 0.03; and r = 0.33, p = 0.003, respectively) while a negative correlation was observed between galectin-3 and albumin (r = -0.31, p = 0.006). Multiple logistic regression analysis revealed that galectin-3 was an independent predictor of mortality in COVID-19 patients (odds ratio [OR] = 2.272, 95% confidence interval [CI] = 1.106-4.667; p = 0.025). When the threshold value for galectin-3 was regarded as 2.8 ng/ml, it was discovered to predict mortality with 80% sensitivity and 57% specificity (area under the curve = 0.738, 95% CI = 0.611-0.866, p = 0.002). Galectin-3 might be a simple, useful, and prognostic biomarker that can be utilized to predict patients who are at high risk of mortality in severe COVID-19 patients.en_US
dc.identifier.doi10.1002/jmv.28494
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue2en_US
dc.identifier.pmid36633201en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.28494
dc.identifier.urihttps://hdl.handle.net/11616/103027
dc.identifier.volume95en_US
dc.identifier.wosWOS:001034949300057en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapelinen_US
dc.subjectbiomarkeren_US
dc.subjectCOVID-19en_US
dc.subjectgalectin-3en_US
dc.subjectmortalityen_US
dc.titleEfficacy of serum apelin and galectin-3 as potential predictors of mortality in severe COVID-19 patientsen_US
dc.typeArticleen_US

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