Cytotoxic effects of cucurbitacin ı and ecballium elaterium on breast cancer cells

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dc.contributor.authorYılmaz, Kadir
dc.contributor.authorKarakuş, Fuat
dc.contributor.authorEyol, Ergül
dc.contributor.authorTosun, Emir
dc.contributor.authorYılmaz, İsmet
dc.contributor.authorUnuvar, Songül
dc.date.accessioned2019-06-21T05:23:15Z
dc.date.available2019-06-21T05:23:15Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The Cul content of E. elaterium fruit juice and chloroform extract was quantified using high performance liquid chromatography. The cytotoxic effects of the fruit juice, chloroform extract and CuI were determined by MTT, wound healing and colony formation assays; all had an anti-proliferative activity on the breast cancer cells. Clarifying the mechanisms of cucurbitacins will enable the identification of new molecular targets for breast cancer therapy.en_US
dc.identifier.citationYilmaz, K . Karakus, F. Eyol, E. Tosun, E. Yilmaz, I . Unuvar, S. (2018). Cytotoxic effects of cucurbitacin ı and ecballium elaterium on breast cancer cells.Cilt:13. Sayı:11. 1445-1448 ss.en_US
dc.identifier.endpage1448en_US
dc.identifier.issue11en_US
dc.identifier.startpage1445en_US
dc.identifier.urihttps://hdl.handle.net/11616/11910
dc.identifier.volume13en_US
dc.language.isoenen_US
dc.publisherNatural product communıcatıonsen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectJSI-124en_US
dc.titleCytotoxic effects of cucurbitacin ı and ecballium elaterium on breast cancer cellsen_US
dc.typeArticleen_US

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