Determination of in vitro Dissolution Profiles of Amlodipine Besylate and Olmesartan Medoxomil Using a New HPLC Method

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dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorCelebier, Mustafa
dc.contributor.authorSahin, Selma
dc.contributor.authorAltinoz, Spode
dc.date.accessioned2024-08-04T20:57:38Z
dc.date.available2024-08-04T20:57:38Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to develop an HPLC method for simultaneous determination of these active compounds and to apply this method to determine the dissolution of AML and OLM from a commercially available tablet. Valsartan (VAL) was used as an internal standard (IS). Separation of AML, OLM and VAL was performed using Phenomenex C-18 column (Luna 5 mu, 100A, 250x4.6 mm; California, USA) protected with a Phenomenex C-18 guard column (4.0x3.0 mm; California, USA). The chromatographic separation operated isocratically at room temperature using a mobile phase consisted of phosphate buffer (pH 4.0, 0.04 mol/L):methanol:acetonitrile (40:45:15, v/v/v) delivered at a flow rate of 0.8 mL/min and injection volume was 10 mu L. The diode array detector was set at 234 nm and 205 nm wavelengths for the quantification of AML and OLM respectively. In vitro dissolution studies revealed that 85% of the labeled amounts of AML and OLM were released within 25 min from their fixed combination tablet dosage form. The developed HPLC method was validated according to the ICH guidelines and it is proposed for dissolution studies of the combination dosage forms of these compounds.en_US
dc.identifier.endpage30en_US
dc.identifier.issn0034-7752
dc.identifier.issue1en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://hdl.handle.net/11616/102795
dc.identifier.volume64en_US
dc.identifier.wosWOS:000315934900005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherChiminform Data S Aen_US
dc.relation.ispartofRevista De Chimieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmlodipine besylateen_US
dc.subjectdissolutionen_US
dc.subjectHPLC methoden_US
dc.subjectOlmesartan medoxomilen_US
dc.titleDetermination of in vitro Dissolution Profiles of Amlodipine Besylate and Olmesartan Medoxomil Using a New HPLC Methoden_US
dc.typeArticleen_US

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