Independent predictors of cardiovascular risk in polycystic ovarian syndrome

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dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorKafkasli, Ayse
dc.contributor.authorMeydanli, Mehmet Mutlu
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorTaskapan, Cagatay
dc.date.accessioned2024-08-04T20:59:02Z
dc.date.available2024-08-04T20:59:02Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe aimed to determine the independent predictors of cardiovascular risk in polycystic ovarian syndrome (PCOS). Ninety-one PCOS and 51 control patients were enrolled to our prospective cross sectional case-control study. In early follicular phase hormonal and lipid profile, fasting insulin and CRP (hs-CRP) levels and glucose levels on fasting and 2 h after the 75 g glucose intake were determined. Insulin resistance (IR) was evaluated with homeostasis model assessment and free testosterone was determined with free androgen index. PCOS was found to be associated with dyslipidemia, hyperandrogenism, IR and sub-clinical inflammation. The prevalence of overweight-obesity (41.8% vs. 25.5%, p = 0.038), IR (42.9% vs. 23.5%, p = 0.035) and glucose intolerance (15.38% vs. 1.96%, p = 0.043) were significantly higher in PCOS compared to control group. Independent predictors of the risk of elevated hs-CRP level were PCOS status (OR = 5, 95% CI: 1.55-16.14, p = 0.007) and high BMI (OR = 4.2, 95% CI: 1.2-14.2, p = 0.022) and high BMI (OR = 1.2, 95% CI: 1.05-1.4, p = 0.007) and of TC/HDL ratio was high BMI (OR = 1.21, 95% CI: 1.05-1.4, p = 0.009) and increasing age (OR = 1.11, 95% CI: 1.01-1.2, p = 0.04). The presence of PCOS, independent from obesity and IR, is the strongest predictor of elevated hs-CRP level. Obesity and advanced age further increases the cardiovascular risk in PCOS.en_US
dc.identifier.doi10.3109/09513590.2010.551566
dc.identifier.endpage919en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue11en_US
dc.identifier.pmid21294689en_US
dc.identifier.startpage915en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2010.551566
dc.identifier.urihttps://hdl.handle.net/11616/103395
dc.identifier.volume27en_US
dc.identifier.wosWOS:000295729200013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic ovarian syndromeen_US
dc.subjectbody mass indexen_US
dc.subjectinsulin resistanceen_US
dc.subjectamenorrheaen_US
dc.subjecthirsutismen_US
dc.titleIndependent predictors of cardiovascular risk in polycystic ovarian syndromeen_US
dc.typeArticleen_US

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