Omega-3 essential fatty acid supplementation and erythrocyte oxidant/antioxidant status in rats

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dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.authorwosidOzgocmen, Salih/K-4680-2019
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidOzgocmen, Salih/K-9588-2015
dc.contributor.authorIraz, M
dc.contributor.authorErdogan, H
dc.contributor.authorOzyurt, B
dc.contributor.authorOzugurlu, F
dc.contributor.authorOzgocmen, S
dc.contributor.authorFadillioglu, E
dc.date.accessioned2024-08-04T21:00:04Z
dc.date.available2024-08-04T21:00:04Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFish oil contains large amounts of essential omega-3 fatty acids, such as eicosapentaenoic and docosahexaneoic acids, which are building structures of cell membranes. The goal of this study was to elucidate the effects of dietary omega-3 fatty acid supplementation on the oxidant/antioxidant status of erythrocytes in rats. The malondialdehyde (MDA) and nitric oxide (NO) levels and the catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) activities were assayed in erythrocytes of male Wistar albino rats after 30 days of dietary supplementation with fish oil (0.4 g/kg/day). Erythrocyte CAT activity in the treated group was increased in comparison with the control group. Erythrocyte MDA and NO levels were lower in the treated group than the controls. Erythrocyte GSH-Px and SOD activities did not differ significantly in the 2 groups. Negative correlations were found between SOD and CAT activities, and between SOD and GSH-Px activities in the treated group. In conclusion, omega-3 fatty acid supplementation helps to prevent lipid peroxidation and to safeguard erythrocytes from oxidative injury. Dietary supplementation with omega-3 fatty acids might possibly protect tissues from oxygen free radical injury in the various diseases in which the oxidant/antioxidant defense mechanisms are disturbed.en_US
dc.identifier.endpage173en_US
dc.identifier.issn0091-7370
dc.identifier.issn1550-8080
dc.identifier.issue2en_US
dc.identifier.pmid15943181en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://hdl.handle.net/11616/103780
dc.identifier.volume35en_US
dc.identifier.wosWOS:000229123600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Clinical Scientistsen_US
dc.relation.ispartofAnnals of Clinical and Laboratory Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfish oilen_US
dc.subjectomega-3 essential fatty acidsen_US
dc.subjectoxidant/antioxidant sten_US
dc.subjectlipid peroxidationen_US
dc.subjectnitric oxideen_US
dc.titleOmega-3 essential fatty acid supplementation and erythrocyte oxidant/antioxidant status in ratsen_US
dc.typeArticleen_US

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