The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage after intestinal obstruction
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turk J Med Sci 2010; 40 (6): 897-903.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Intestinal obstruction (IO) induces bacterial translocation due to failure of the intestinal barrier function. Following
bacterial overgrowth, its degradation products play a decisive role in the development of systemic septic complications.
The aim of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on bacterial translocation and
intestinal damage in an IO model in rats.
Materials and methods: Complete IO was created in the distal ileum of rats by a single 4-0 silk suture. A total of 21
Wistar albino rats were randomized into 3 groups: Group 1, Sham (n = 7); Group 2, IO (n = 7); Group 3, IO + CAPE (n
= 7). Group 3 received a 10 μmol kg-1 dose of CAPE intraperitoneally. This treatment was continued for 3 days (2 days
before surgery and 1 day after surgery). Samples of mesenteric lymph nodes (MLN), liver, and segmental ilea were
obtained 24 h after the mechanical bowel obstruction, both for biochemical analysis and microbiological examination.
Results: The most common bacteria cultured from the liver and MLN of these animals were Escherichia coli, Proteus
mirabilis, and Enterococcus spp. In the CAPE-treated rats, the malondialdehyde (MDA) and adrenomedullin levels were
significantly lower than in the IO group (P < 0.001). The reduced glutathione (GSH) and catalase (CAT) levels of the ileum
were found to be significantly higher in the CAPE-treated rats than those in the IO group (P < 0.001).
Conclusion: These results have shown that CAPE may have protective effects against bacterial translocation and intestinal
oxidative damage in mechanical IO. More experimental studies are needed to explain the exact mechanism of this
beneficial effect.
Açıklama
Turk J Med Sci 2010; 40 (6): 897-903.
Anahtar Kelimeler
Intestinal obstruction, Bacterial translocation, Caffeic acid phenethyl ester (CAPE), Oxidative stress, Adrenomedullin
Kaynak
Turk J Med Sci 2010; 40 (6): 897-903.
WoS Q Değeri
Scopus Q Değeri
Cilt
40
Sayı
6
Künye
Ara, C., Dirican, A., Erdoğan, S., Ateş, B., Özgör, D., Tatlı, F., … Vedat, K. (2010). The Effect Of Caffeic Acid Phenethyl Ester On Bacterial Translocation And İntestinal Damage After İntestinal Obstruction. Turkısh Journal Of Medıcal Scıences, 0–0.
