Effect of caffeic acid phenethyl ester in doxorubicin induced descending aorta damage

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dc.contributor.authorDisli, Olcay Murat
dc.contributor.authorErdil, Nevzat
dc.contributor.authorAkca, Baris
dc.contributor.authorOzhan, Onural
dc.contributor.authorDurhan, Merve
dc.contributor.authorYildiz, Azibe
dc.contributor.authorCigremis, Yilmaz
dc.date.accessioned2026-04-04T13:30:41Z
dc.date.available2026-04-04T13:30:41Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractDoxorubicin (DOX), a chemotherapeutic agent used in cancer treatment, can cause cardiotoxicity as an adverse effect. In this study, potential protective effect of Caffeic acid phenethyl ester (CAPE), a well-known antioxidant agent, was investigated in doxorubicin induced aortic damage model. Total of 28 adult Wistar albino rats were equally divided into four groups as: Control, DOX, CAPE+DOX, CAPE. Accordingly, 10 mu mol/kg CAPE for 10 days and/or 10 mg/kg doxorubicin for 3 days was given intraperitoneally. Control group received saline and ethanol as the vehicles of doxorubicin and CAPE, respectively. GSH, MDA, CuZn-SOD and CAT levels in descending aorta were investigated as the oxidative stress markers and histopathological changes were evaluated. GSH level was significantly higher in CAPE group as compared to the other groups (P <0.05) while there were no significant differences in MDA, CuZn-SOD and CAT levels among the groups (P>0.05). In microscopic view, tunica media of aorta was significantly thinner in DOX group as compared to CAPE group. Tunica media thickness significantly increased in CAPE+DOX group as compared to DOX group. CAPE treatment ameliorates the histopathological changes that are characterized by the reduced wall thickness induced by doxorubicin. However, CAPE treatment did not seem to effect biochemical parameters that are indicative of oxidative stress. The results indicated that CAPE can be protective against doxorubicin induced aortic vessel damage.
dc.description.sponsorshipResearch fund of Inonu University Scientific Research Project unit, (BAP) [TSA-2022-2881]
dc.description.sponsorshipThis study was supported by the research fund of Inonu University Scientific Research Project unit, (BAP, TSA-2022-2881).
dc.identifier.doi10.56042/ijeb.v62i11.10136
dc.identifier.endpage930
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue11
dc.identifier.orcid0000-0002-8275-840X
dc.identifier.startpage925
dc.identifier.urihttps://doi.org/10.56042/ijeb.v62i11.10136
dc.identifier.urihttps://hdl.handle.net/11616/108294
dc.identifier.volume62
dc.identifier.wosWOS:001376388900008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Experimental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCAPE
dc.subjectDoxorubicin
dc.subjectAorta
dc.subjectAntioxidant
dc.subjectRat
dc.titleEffect of caffeic acid phenethyl ester in doxorubicin induced descending aorta damage
dc.typeArticle

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