SERUM GHRELIN LEVELS DURING FRACTURE HEALING AND IMMUNOHISTOCHEMICAL INVESTIGATION OF GHRELIN IN BONE TISSUE

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dc.authoridİnanmaz, Erkan/0000-0002-9555-0325
dc.authorwosidBentli, Recep/AAB-4140-2021
dc.authorwosidİnanmaz, Erkan/HHZ-3660-2022
dc.contributor.authorEmeli, Adem
dc.contributor.authorInanmaz, Mustafa Erkan
dc.contributor.authorIsik, Cengiz
dc.contributor.authorBentli, Recep
dc.contributor.authorKarakurt, Locman
dc.contributor.authorBelhan, Oktay
dc.date.accessioned2024-08-04T21:01:08Z
dc.date.available2024-08-04T21:01:08Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Ghrelin is a hormone with efficacy on increasing osteoblastic cell proliferation, differentiation, growth hormone release, and preventing apoptosis. The present study aimed to investigate whether ghrelin has a role in bone fracture healing process and presence in the bone tissue. Patients and methods: Blood samples of 10 patients, who underwent surgery for fracture repair, were obtained for 4 times in the manner that; before fracture stabilization (preoperative) and on the postoperative lst, 10th, and 60th days. Additionally, blood samples were obtained from 10 healthy subjects (control group). Ghrelin levels in serum samples were measured by enzyme-linked immunosorbent assay method and presence of ghrelin was imnzunohistochemically investigated in bone tissue samples. Results: Although no difference was found between the groups in terms of blood levels of ghrelin, it was observed that acylated ghrelin level was increased beginning from the postoperative 1st day as compared to the control group. Des-acylated ghrelin levels were also increased as compared to the controls, except for the postoperative 10th day. Ghrelin was not detected in bone tissues. Osseous union was observed in all patients of the fracture group. Conclusions: we thought that increased acylated and des-acylated ghrelin levels were contributed to fracture healing process by means of enhancing cell proliferation, preventing apoptosis, presenting anti-inflammatory and antimicrobial effect and increasing growth hormone release.en_US
dc.identifier.endpage142en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue1en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://hdl.handle.net/11616/104109
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335937700022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFracture healingen_US
dc.subjectghrelinen_US
dc.subjectbone tissueen_US
dc.titleSERUM GHRELIN LEVELS DURING FRACTURE HEALING AND IMMUNOHISTOCHEMICAL INVESTIGATION OF GHRELIN IN BONE TISSUEen_US
dc.typeArticleen_US

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