Protective effects of quercetin against sepsis-induced oxidative damage on rat kidneys

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dc.authoridaydın turk, bilge/0000-0003-1592-1040
dc.authoridduran, mehmet/0000-0001-7568-3537
dc.authoridbicakcioglu, murat/0000-0001-9101-6857
dc.authoridYILMAZ, NEZIR/0000-0002-4351-6256
dc.authorwosidaydın turk, bilge/HKV-4966-2023
dc.authorwosidduran, mehmet/GXH-1815-2022
dc.authorwosiddoğukan, mevlüt/HJY-5235-2023
dc.authorwosidbicakcioglu, murat/AAA-8149-2022
dc.authorwosidYılmaz, Nezir/JHT-9123-2023
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.contributor.authorDuran, Mehmet
dc.contributor.authorBicakcioglu, Murat
dc.contributor.authorYilmaz, Nezir
dc.contributor.authorTurk, Bilge Aydin
dc.contributor.authorDogukan, Mevlut
dc.contributor.authorNakir, Hamza
dc.contributor.authorDogan, Zumrut
dc.date.accessioned2024-08-04T21:00:56Z
dc.date.available2024-08-04T21:00:56Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Sepsis is a clinical pathology, characterized by a severe and exaggerated inflammatory response. One of the most frequently damaged organs in sepsis is the kidney. Quercetin has anti-inflammatory, anti-proliferative, and antioxidant effects. In this study. it was aimed to examine the protective effects of quercetin on the kidneys. Material and Methods: In the scope of this study, 31 rats were planned to be used in the experiments. The groups and number of animals were as follows: Group 1:1.5 ml saline, Group 2: 1.5 ml olive oil, Group 3: intestinal ligation and puncture procedure was used to create experimental sepsis method. Group 4:20 mg/kg quercetin was administrated by gavage. Group 5: quercetin was administered in intragastrically at doses of 20 mg/kg. In biochemical analyzes of kidney tissue samples, BUN, creatinine, MDA and GSH values were checked. Cell damage, inflammation and fibrosis were evaluated histopathologically. Results: As a result of this study, tissue GSH levels were significantly different between groups 3 and 4 (p- 0.001). In terms of BUN value, it was found to be significantly higher in group 3 (p= 0.002). In tissue histology, glomerulitis (p, 0.001), tubular cell necrosis (p= 0.001) and mesenchymal matrix increase (p= 0.001) were different between groups 3 and 4. Finally, no fibrosis was observed in any group (p> 0.05). Discussion: Quercetin has protective effects on kidney tissue against organ damage caused by sepsis.en_US
dc.identifier.doi10.4328/ACAM.21057
dc.identifier.endpage339en_US
dc.identifier.issn2667-663X
dc.identifier.issue3en_US
dc.identifier.startpage335en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.21057
dc.identifier.urihttps://hdl.handle.net/11616/103946
dc.identifier.volume13en_US
dc.identifier.wosWOS:000782124600023en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectQuercetinen_US
dc.subjectSepsisen_US
dc.subjectAntioxidanten_US
dc.subjectCecal Ligationen_US
dc.titleProtective effects of quercetin against sepsis-induced oxidative damage on rat kidneysen_US
dc.typeArticleen_US

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