Proton MR spectroscopy features of normal appearing white matter neurofibromatosis type 1

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dc.authorid7768en_US
dc.contributor.authorAlkan, Alpay
dc.contributor.authorSaraç, Kaya
dc.contributor.authorKutlu, Ramazan
dc.contributor.authorYakıncı, Mehmet Cengiz
dc.contributor.authorSığırcı, Ahmet
dc.contributor.authorAslan, Mehmet
dc.contributor.authorÖzcan, Hamdi
dc.contributor.authorYoloğlu, Saim
dc.date.accessioned2017-06-24T06:24:08Z
dc.date.available2017-06-24T06:24:08Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo determine whether differences exist between neurofibromatosis type 1 (NF1) patients with or without focal lesions and healthy normal volunteers in the metabolite ratios of normal appearing white matter, 27 patients with NF1 (with parenchymal lesion, MR positive, n: 17; without parenchymal lesions, MR negative, n: 10) and 20 healthy volunteers underwent MRI and short TE (31 ms) proton MR spectroscopy (MRS). In 17 patients with parenchymal lesions, 61 focal lesions were detected by MRI. MRS was performed from normal appearing frontal and posterior parietal white matter (FWM and PWM) in NF1 and from control groups. NAA/Cr, Cho/Cr and MI/Cr ratios were calculated. Significant increase in Cho/Cr and MI/Cr ratios were found in FWM and PWM in MR negative and positive groups when compared to control group. NAA/Cr ratio in MR positive group was significantly decreased in FWM compared to control group. There were no significant differences between FWM and PWM in all metabolite ratios of MR negative group. MI/Cr ratio in MR positive group was significantly elevated in PWM compared to FWM. Metabolite changes detected by MRS could indicate demyelination and gliosis in normal appearing white matter in all NF1 patients, and additionally neuroaxonal damage in the FWM of NF1 patients with focal lesions. For that reason, in the clinical evaluation and follow-up of these patients MRS features of normal appearing white matter should be considered in addition to focal lesions.en_US
dc.identifier.citationAlkan, A. Saraç, K. Kutlu, R. Yakıncı, M. C. Sığırcı, A. Aslan, M. Özcan, H. Yoloğlu, S. (2003). Proton MR spectroscopy features of normal appearing white matter neurofibromatosis type 1. Magn Reson Imaging, (21), 1049–1053.en_US
dc.identifier.endpage1053en_US
dc.identifier.startpage1049en_US
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9D-4B963BX-M&_user=746906&_coverDate=11%2F30%2F2003&_alid=1651061172&_rdoc=7&_fmt=high&_orig=search&_origin=search&_zone=rslt_list_item&_c
dc.identifier.urihttps://hdl.handle.net/11616/7169
dc.identifier.volume21en_US
dc.language.isoenen_US
dc.publisherMagn Reson Imagingen_US
dc.relation.ispartofMagn Reson Imagingen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeurofibromatosis type 1en_US
dc.subjectMagnetic resonance spectroscopyen_US
dc.subjectWhite matteren_US
dc.titleProton MR spectroscopy features of normal appearing white matter neurofibromatosis type 1en_US
dc.typeArticleen_US

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