Pathogens of ıntensive care unit-acquired ınfections and their antimicrobial resistance: a 9-yearanalysis of data from a university hospital
| dc.contributor.author | Yetkin, Funda | |
| dc.contributor.author | Yakupogullari, Yusuf | |
| dc.contributor.author | Kuzucu, Cigdem | |
| dc.contributor.author | Ersoy, Yasemin | |
| dc.contributor.author | Otlu, Baris | |
| dc.contributor.author | Colak, Cemil | |
| dc.contributor.author | Parmaksiz, Nalan | |
| dc.date.accessioned | 2019-07-18T10:27:50Z | |
| dc.date.available | 2019-07-18T10:27:50Z | |
| dc.date.issued | 2018 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Background: Pathogens surveillance and antimicrobial resistance are essential for the prompt organization of therapeutic and preventive actions in healthcare settings. Objectives: We investigated the causative agents of intensive care unit (ICU)-acquired infections and their antimicrobial resistance in a university hospital over a nine-year period. Methods: An active, prospective surveillance was conducted in the ICUs of a tertiary care hospital between 2007 and 2015. The changing patterns in the frequency of pathogens and their antimicrobial resistance by the time were statistically evaluated with Mann-Whitney U test. Results: A total of 3044 pathogens were isolated from 4272 healthcare-associated infections attacks in 3437 patients. The most frequently detected organisms were Acinetobacter spp. (n = 1060, 34.8%), Pseudomonas aeruginosa (n = 622, 20.4%), Escherichia coli (n = 340, 11.1%), Klebsiella pneumoniae (n = 331, 10.8%), and Candida spp. (n = 285, 9.3%). Carbapenem resistance among Acinetobacter spp., P. aeruginosa, E. coli, and K. pneumoniae was found as 82%, 30.7%, 2%, and 9.3%, respectively. The prevalence of extended-spectrum betalactamase (ESBL) among E. coli and K. pneumoniae was 49.7% and 41.3%, orderly, and methicillin resistance in Staphylococcus aureus was 81.8%. Substantial reductions occurred in the rates of E. coli (16.8% to 8.9%), S. aureus (11% to 3.2%), coagulase-negative staphylococci (7.9% to 0), and Stenotrophomonas maltophilia (4.2% to 0.3%) during the study period by the applied infection control measures while the rate of Acinetobacter spp. (9.7% to 51%) significantly increased. Furthermore, the increases in the carbapenem resistance among Acinetobacter spp. (52.5% to 91.4%), Pseudomonas spp. (25.7% to 51.6%), E. coli (0 to 12.7%), and K. pneumoniae (2.6% to 9%) and the decrease in the prevalence of ESBL-producing E. coli (57% to 27.2%) were statistically significant. Conclusions: Despite the decreases in the frequencies of staphylococci and some Gram-negative bacteria, the current infection control measures have been unable to limit the spread of carbapenem-resistant Gram-negative bacteria in our facility. Additional precautions are required to control such pathogens in the intensive care units. | en_US |
| dc.identifier.citation | Yetkin, F. Yakupogullari, Y. Kuzucu, C . Ersoy, Y . Otlu, B .Colak, C. Parmaksiz, N.(2018). Pathogens of ıntensive care unit-acquired ınfections and their antimicrobial resistance: a 9-yearanalysis of data from a university hospital.Cilt:11. Sayı:10 . | en_US |
| dc.identifier.doi | 10.5812/jjm.67716 | en_US |
| dc.identifier.endpage | 0 | en_US |
| dc.identifier.issue | 10 | en_US |
| dc.identifier.startpage | 0 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/12740 | |
| dc.identifier.volume | 11 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Ahvaz jundıshapur unıv med scı, po box 6357-33118, ahvaz, 00000, ıran | en_US |
| dc.relation.ispartof | Jundıshapur journal of mıcrobıology | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Blood-stream ınfectıons | en_US |
| dc.subject | acınetobacter-baumannıı | en_US |
| dc.subject | nosocomıal ınfectıons | en_US |
| dc.subject | multıdrug-resıstance | en_US |
| dc.subject | rısk-factors | en_US |
| dc.subject | epıdemıology | en_US |
| dc.subject | surveıllance | en_US |
| dc.subject | turkey | en_US |
| dc.subject | multıcenter | en_US |
| dc.subject | prevalence | en_US |
| dc.title | Pathogens of ıntensive care unit-acquired ınfections and their antimicrobial resistance: a 9-yearanalysis of data from a university hospital | en_US |
| dc.type | Article | en_US |
