Development of paclitaxel and flurbiprofen co-loaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett-Burman design

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dc.authoridTonbul, Hayrettin/0000-0001-5510-8973
dc.authoridŞahin, Adem/0000-0002-3996-2931;
dc.authorwosidYerlikaya, Firat/ABB-3153-2021
dc.authorwosidAktaş, Yeşim/ABB-3264-2020
dc.authorwosidTonbul, Hayrettin/AAR-6961-2020
dc.authorwosidŞahin, Adem/IYT-0077-2023
dc.authorwosidÇapan, Yılmaz/AAM-5292-2021
dc.contributor.authorSahin, Adem
dc.contributor.authorCaban-Toktas, Secil
dc.contributor.authorTonbul, Hayrettin
dc.contributor.authorYerlikaya, Firat
dc.contributor.authorAktas, Yesim
dc.contributor.authorCapan, Yilmaz
dc.date.accessioned2024-08-04T20:57:41Z
dc.date.available2024-08-04T20:57:41Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNano drug co-delivery system is a popular strategy for combined application of two or more anticancer and/or synergistic drugs. Synergistic effects of nonsteroidal anti-inflammatory drugs and anti-cancer drugs in cancer treatment are shown in the literature. This study aimed to screen and understand the critical formulation and process parameters in the preparation of flurbiprofen and paclitaxel co-loaded nanoparticles to develop an anti-cancer nano co-delivery system. With this aim, critical parameters were determined using the Plackett-Burman experimental design (DoE). Flurbiprofen and paclitaxel drug loading amounts were considered as critical quality attributes to control the effective drug loading ratio. Furthermore, average particle size and zeta potential were also defined as critical quality attributes in order to optimize passive drug targeting and colloidal stability. Surfactant type was determined as the most significant factor for the average particle size and zeta potential. For flurbiprofen and paclitaxel drug loading into the nanoparticles, amounts of both flurbiprofen and paclitaxel were determined as critical factors. Consequently, paclitaxel and flurbiprofen were efficiently loaded into nanoparticles, and the impact of the formulation variables was successfully screened by a DoE. By controlling the determined parameters, the therapeutic efficacy of co-loaded drug nanoparticles could be maximized in further studies.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination Unit [014 D07 301 004-669]en_US
dc.description.sponsorshipThis research was supported by Hacettepe University Scientific Research Projects Coordination Unit [grant numbers: 014 D07 301 004-669].en_US
dc.identifier.doi10.26650/IstanbulJPharm.2019.19036
dc.identifier.endpage166en_US
dc.identifier.issn2587-2087
dc.identifier.issue3en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2019.19036
dc.identifier.urihttps://hdl.handle.net/11616/102820
dc.identifier.volume49en_US
dc.identifier.wosWOS:000511129700008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNanoparticlesen_US
dc.subjectpaclitaxelen_US
dc.subjectflurbiprofenen_US
dc.subjectPLGAen_US
dc.subjectdesign of experimentsen_US
dc.subjectPlackett-Burmanen_US
dc.titleDevelopment of paclitaxel and flurbiprofen co-loaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett-Burman designen_US
dc.typeArticleen_US

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