Prevalence and Predictive Clinical Characteristics of Metabolically Healthy Obesity in Obese Children and Adolescents

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dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authorwosidDundar, Ismail/ABG-2027-2021
dc.contributor.authorDundar, Ismail
dc.contributor.authorAkinci, Aysehan
dc.date.accessioned2024-08-04T21:00:54Z
dc.date.available2024-08-04T21:00:54Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The increasing prevalence of childhood obesity and accompanying comorbidities all over the world constitutes one of the most important public health problems of the changing world. The frequency and causes of the metabolically healthy obesity (MHO) phenotype in children is not clear. Objective: The objective is to determine the prevalence of the MHO phenotype in obese Turkish children and adolescents and to identify clinical and biochemical indicators for this phenotype. Methods: Eight hundred forty-seven obese children and adolescents, aged 3-18 years with BMI-SDS >+2 SD from the obesity outpatient clinic were included. Demographic, anthropometric, and physical examination information was collected from patient medical files. In addition, obesity-related comorbidities and results of laboratory tests were obtained. For study purposes, obese patients with no cardiometabolic risk factors were accepted as MHO, and those with ???1 cardiometabolic risk factor were considered metabolically unhealthy obese (MUO). MHO was defined according to Damanhoury's criteria. Results: Out of 847 children (mean age 10.6??3.4 years) who met the study criteria, 289 (34.1%) were diagnosed with MHO. Being younger, prepubertal, having relatively low BMI, low waist/hip ratio, low insulin resistance (HOMA-IR) index, high high-density lipoprotein, low triglyceride, low fasting insulin and glucose levels, low uric acid and low alanine transaminase (ALT) levels were associated with MHO. Conclusions: The MHO phenotype was present in just over a third of this obese pediatric cohort. The most important factors associated with MHO; age, waist-hip ratio, and BMI were determined.en_US
dc.identifier.doi10.7759/cureus.35935
dc.identifier.issn2168-8184
dc.identifier.issue3en_US
dc.identifier.pmid37038589en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.35935
dc.identifier.urihttps://hdl.handle.net/11616/103899
dc.identifier.volume15en_US
dc.identifier.wosWOS:000980798000034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectobesityen_US
dc.subjectchildhood obesityen_US
dc.subjectmetabolically unhealthy obesityen_US
dc.subjectmetabolically healthy obesityen_US
dc.subjectmetabolic syndromeen_US
dc.titlePrevalence and Predictive Clinical Characteristics of Metabolically Healthy Obesity in Obese Children and Adolescentsen_US
dc.typeArticleen_US

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