Is the use of Tenofovir Dipivoxil fumarate effective and safe in preventing vertical transmission in pregnant women with chronic HBV with high viral load?

Basit Öğe Kaydı
dc.contributor.authorAladag, H.
dc.contributor.authorAladag, M.
dc.date.accessioned2024-08-04T20:59:47Z
dc.date.available2024-08-04T20:59:47Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: In our country, transmission from mother to baby is the most common form of transmission of viral hepatitis B. A high viral load in the mother and HBeAg positivity pose the greatest risk of transmission from mother to baby. The best way to pre-vent this is to try to eliminate the viral load in the mother by using a strong antiviral such as prenatal TDF in mothers with a high viral load during pregnancy. This study aimed to evaluate the efficacy and safety of TDF in pregnant women with high viral load.PATIENTS AND METHODS: Seventy patients with hepatitis B e-antigen positive and negative were included in the retrospective study conducted in our clinic. In 35 cases, pregnant women with HBeAg (+) positive chronic HBV and HBV-DNA levels of 107 copies/mL were be-tween 18 and 27 weeks of pregnancy. The preg-nant women took 300 mg of TDF per day. There were 35 untreated HBeAg-negative, chronic HBV patients in the control group. Babies born to HBeAg-positive and HBeAg-negative mothers are given an initial dose of 200 IU of hepatitis B immune globulin (HBIG) and 20 g of recombi-nant hepatitis B vaccine in the first 12 hours af-ter birth, followed by 4, 8, and 24 weeks. HBsAg and HBV-DNA findings were examined in new-born serum 28 weeks after birth.RESULTS: Postpartum 28 weeks, none of the babies born to HBeAg-positive mothers treated with TDF had HBsAg positivity, while 3.5% of babies born to HBeAg-negative mothers and not treated with TDF had HBsAg positivity and immunoprophylaxis failure. There was no statistically significant difference between the treatment and control groups regarding maternal height, weight, gestational age, or congenital malformations (p<0.05). There was no signifi-cant difference between the side effects seen in mothers. In the examination performed at the 28th week postpartum, a statistically signifi-cant decrease in HBV-DNA levels was observed in mothers who received TDF treatment com-pared to those who did not (88.5%) (p<0.05). In 31 of the 35 patients receiving TDF treatment, ALT was reported to be normalized in 25 of the 35 patients who did not receive TDF treatment (p<0.05).CONCLUSIONS: It has been observed that the use of TDF, which has a strong efficacy and high barrier, in the second and/or third trimester of pregnancy reduces transmission rates without causing side effects in both the mother and the newborn, thereby preventing vertical transmission of viral hepatitis B from the mother to child.en_US
dc.identifier.endpage2098en_US
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid36930508en_US
dc.identifier.startpage2091en_US
dc.identifier.urihttps://hdl.handle.net/11616/103525
dc.identifier.volume27en_US
dc.identifier.wosWOS:000960863600009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTelbivudineen_US
dc.subjectHBeAgen_US
dc.subjectLamivudine (LAM)en_US
dc.subjectTelbivu-dine (TBV)en_US
dc.subjectNewbornen_US
dc.subjectPregnancyen_US
dc.titleIs the use of Tenofovir Dipivoxil fumarate effective and safe in preventing vertical transmission in pregnant women with chronic HBV with high viral load?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu