Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer

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dc.contributor.authorYılmaz, Ercan
dc.contributor.authorGül, Mehmet
dc.contributor.authorMelekoğlu, Rauf
dc.contributor.authorCoşkun, Ebru İnci
dc.contributor.authorGül, Semir
dc.contributor.authorBaştemur, Ayşe Gülçin
dc.date.accessioned2019-07-22T06:13:09Z
dc.date.available2019-07-22T06:13:09Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer. Methods The study participants were divided into patients with benign endometrial pathologies (Group 1, n=23), patients with endometrial hyperplasia (Group 2, n=21) and patients with endometrial cancer (Group 3, n=20). NEDD4L expression was detected by immunohistochemical staining and H scores were calculated to standardize staining intensity. Statistical analysis was performed using SPSS 16.0. Results NEDD4L expression levels according to H scores were significantly lower in patients diagnosed with endometrial cancer compared with those with benign endometrial pathologies. Conclusion NEDD4L is involved in maintaining cell stability, and reduced NEDD4L expression as a result of gene mutation may disrupt this balance in favor of tumorigenesis.en_US
dc.identifier.citationYılmaz, E. Gül, M. Melekoğlu, R. Coşkun, Eİ. Gül, S. Baştemur, AG. (2018). Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer. Cilt:46 Sayı:9, 3709-3716 ss.en_US
dc.identifier.doi10.1177/0300060518777944en_US
dc.identifier.endpage3716en_US
dc.identifier.issue9en_US
dc.identifier.startpage3709en_US
dc.identifier.urihttps://hdl.handle.net/11616/12802
dc.identifier.volume46en_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLANDen_US
dc.relation.ispartofJournal of ınternatıonal medıcal researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNedd4l Expressıonen_US
dc.subjectDegradatıonen_US
dc.subjectPrognosısen_US
dc.subjectReceptoren_US
dc.subjectGeneen_US
dc.titleNeural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial canceren_US
dc.typeArticleen_US

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