Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms

Basit Öğe Kaydı
dc.authoridGurbuz, Sukru/0000-0003-2616-0304
dc.authoridAteşçelik, Metin/0009-0004-4441-6056;
dc.authorwosidGurbuz, Sukru/ABI-3276-2020
dc.authorwosidkargün, kürşat/W-9574-2018
dc.authorwosidalataş, ömer doğan/AEV-4992-2022
dc.authorwosidalataş, ömer doğan/KUD-3716-2024
dc.authorwosidAtescelik, Metin/V-8844-2018
dc.authorwosidAteşçelik, Metin/HPC-6434-2023
dc.authorwosidGurger, Mehtap/V-8219-2018
dc.contributor.authorGurbuz, Sukru
dc.contributor.authorYildiz, Mustafa
dc.contributor.authorKara, Murat
dc.contributor.authorKargun, Kursat
dc.contributor.authorGurger, Mehtap
dc.contributor.authorAtescelik, Metin
dc.contributor.authorAlatas, Omer Dogan
dc.date.accessioned2024-08-04T21:00:09Z
dc.date.available2024-08-04T21:00:09Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease (COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase (PON) enzyme that protects low density lipoproteins (LDL) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192R, L55M genes of patients with COPD. METHODS: DNAs extraction was obtained from blood samples of 50 patients diagnosed with COPD and 50 patients as a control group who were presented to emergency clinic. Genotypes were obtained with polymerase chain reaction (PCR) and AIw I and Hsp92II restriction enzymes were used for Q192R and L55M polymorphisms, respectively. Analysis of data was done with the Chi-square test and Fisher's exact test. RESULTS: A statistically significant difference in Q192R polymorphism was found between the COPD patients and the control group (P=0.05). There was no statistically significant difference in L55M polymorphisms between the patient and control groups (P>0.05). Q192R polymorphism was significantly correlated with the PON1 gene and cigarette smoking; however other risk factors did not show any significant correlation with this polymorphism. Though L55M polymorphism was significantly correlated with family history and tuberculosis, there was no significant correlation with other risk factors. CONCLUSION: We believe that more studies are needed to study the correlation of L55M polymorphism with other factors.en_US
dc.identifier.doi10.5847/wjem.j.1920-8642.2015.03.007
dc.identifier.endpage206en_US
dc.identifier.issn1920-8642
dc.identifier.issue3en_US
dc.identifier.pmid26401181en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.5847/wjem.j.1920-8642.2015.03.007
dc.identifier.urihttps://hdl.handle.net/11616/103830
dc.identifier.volume6en_US
dc.identifier.wosWOS:000382242400007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherZhejiang Univ Sch Medicineen_US
dc.relation.ispartofWorld Journal of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectParaoxonaseen_US
dc.subjectPolymorphismen_US
dc.subjectAcute attacken_US
dc.titleParaoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphismsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu