Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case-control study

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dc.authoridGORKEM, Umit/0000-0002-0848-9731
dc.contributor.authorGorkem, Umit
dc.contributor.authorYildirim, Engin
dc.date.accessioned2024-08-04T20:56:24Z
dc.date.available2024-08-04T20:56:24Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim There is scant evidence concerning the relationship of alarin concentrations for polycystic ovary syndrome (PCOS) status in the existing literature. Therefore, we aimed to reveal the relationship about predictive value of serum alarin concentrations for PCOS risk in infertile women. Methods This prospective case-control study included a total of 151 infertile women who met eligibility criteria of the study. Infertile women diagnosed with PCOS formed the study group (n = 80). Women with diagnoses of unexplained infertility constituted the control group (n = 71). The biochemical analyses of serum concentrations of lipid profiles, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH) and alarin were performed. Results There were no differences for the study parameters, including age, body mass index, fasting glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total triglyceride, E2, and FSH levels in either group. Serum LH, AMH, alarin concentrations, and antral follicle counts had higher values in the PCOS group compared with the controls. Correlation analysis revealed that serum alarin levels were significantly positively correlated with LH and AMH levels, only in the PCOS group. Multivariate binary logistic regression analysis demonstrated that infertile women with high alarin concentrations were significantly more likely to develop PCOS (OR = 1.77, 95% CI = 0.095-0.332, p < 0.001). Conclusion Higher serum concentrations of alarin and a positive correlation with serum LH levels were found in infertile women with PCOS. This evidence supported that high alarin concentrations might play a role in the development of PCOS.en_US
dc.description.sponsorshipDepartment of Scientific Research Projects of Hitit University, Corum, Turkey [TIP19001.20.001]en_US
dc.description.sponsorshipThe authors would like to thank the members of Hitit University, Department of Reproductive Endocrinology for their valuable contributions. This research (grant number: TIP19001.20.001) was supported by the Department of Scientific Research Projects of Hitit University, Corum, Turkey.en_US
dc.identifier.doi10.1111/jog.15176
dc.identifier.endpage986en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue4en_US
dc.identifier.pmid35174578en_US
dc.identifier.startpage980en_US
dc.identifier.urihttps://doi.org/10.1111/jog.15176
dc.identifier.urihttps://hdl.handle.net/11616/102290
dc.identifier.volume48en_US
dc.identifier.wosWOS:000756062700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalarinen_US
dc.subjectinfertilityen_US
dc.subjectluteinizing hormoneen_US
dc.subjectpolycystic ovary syndromeen_US
dc.titleAlarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case-control studyen_US
dc.typeArticleen_US

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