Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?

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dc.authoridPOYRAZ, AHMET KURSAD/0000-0001-8992-1743
dc.authoridTelo, Selda/0000-0003-3655-0269
dc.authorwosidKaya, Arzu/W-7138-2018
dc.authorwosidTelo, Selda/V-5992-2018
dc.authorwosidYildirim, Tulay/AAB-5030-2021
dc.authorwosidPOYRAZ, AHMET KURSAD/B-7716-2009
dc.authorwosidTelo, Selda/V-6019-2018
dc.contributor.authorAkgtol, Gurkan
dc.contributor.authorUlusoy, Hasan
dc.contributor.authorTelo, Selda
dc.contributor.authorGuslkesen, Arif
dc.contributor.authorYildirim, Tulay
dc.contributor.authorPoyraz, Ahmet Kursad
dc.contributor.authorKaya, Arzu
dc.date.accessioned2024-08-04T20:59:46Z
dc.date.available2024-08-04T20:59:46Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: This study aims to evaluate serum 4-hydroxynonenal (4-HNE) levels and its clinical and radiological significance in patients with rheumatoid arthritis (RA). Patients and methods: The study included 40 patients (8 males, 32 females; mean age 51.4 +/- 11.2 years; range 24 to 72 years) with RA and 30 healthy controls (8 males, 32 females; mean age 53.0 +/- 11.7 years; range 24 to 72 years. Serum 4-HNE levels were measured using sandwich enzyme-linked immunosorbent assay method. Patients with disease activity score 28 <= 3.2 and >3.2 were allocated into low and high/moderate disease activity groups, respectively. Additionally, patients were divided into two groups as early RA (disease duration <= 2 years) and established RA (disease duration >= 2 years). Functional disability was evaluated using health assessment questionnaire. Radiographs were scored using the modified Larsen scoring. Results: Serum 4-HNE levels in patients with RA were significantly higher than controls (p=0.001). Serum 4-HNE levels did not correlate with laboratory or clinical parameters of disease activity including erythrocyte sedimentation rate, C-reactive protein, disease activity score 28, and health assessment questionnaire. Serum 4-HNE levels were higher in patients with established RA than patients with early RA (r=0.487, p=0.001). Besides, modified Larsen score which indicates structural damage correlated significantly with serum 4-HNE levels (p=0.001). Conclusion: These results indicate that serum 4-HNE levels may be used as an indicator for structural damage such as erosions in the early stage of RA; however, they are not efficient to monitor disease activity.en_US
dc.identifier.doi10.5606/ArchRheumatol.2016.5945
dc.identifier.endpage81en_US
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue1en_US
dc.identifier.pmid29900979en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.5606/ArchRheumatol.2016.5945
dc.identifier.urihttps://hdl.handle.net/11616/103506
dc.identifier.volume31en_US
dc.identifier.wosWOS:000372922300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject4-hydroxynonenalen_US
dc.subjectdisease activityen_US
dc.subjectmodified Larsen scoreen_US
dc.subjectrheumatoid arthritisen_US
dc.titleIs 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?en_US
dc.typeArticleen_US

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