Protective Effects of Melatonin and ?-D-Glucan Against Liver Injury in Rats - a Comparative Study

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dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.contributor.authorAydogan, Mustafa Said
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorPolat, Aladdin
dc.contributor.authorYucel, Aytac
dc.contributor.authorOzgul, Ulku
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorDuran, Zeynep Rumeysa
dc.date.accessioned2024-08-04T21:00:56Z
dc.date.available2024-08-04T21:00:56Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. The aim of this study was to investigate the possible protective effects of melatonin and beta-D-glucan against ischemia-reperfusion (IR) injury in rats. Materials and Methods. Forty rats were randomly divided into 5 groups, each consisting of 8 animals, as follows. Sham group [S], IR group [C], IR + beta-Glucan group [beta], IR + melatonin group [MLT], IR + melatonin + beta-Glucan group [MLT + beta]. The rats in the C, beta, MLT and MLT + beta groups were subjected to IR for 60 min each. Melatonin (10 mg.kg(-1)) was intraperitoneally injected for a single dose 30 min before IR. beta-Glucan (50 mg.kg(-1).day(-1)) was orally administered for 10 days to rats. All of the rats were killed on day 11, and histological changes in the liver and tissue levels of oxidants and antioxidants were evaluated. Results. Malondialdehyde [MDA] level were significantly higher in the C group compared to the S group (p = 0.007). MDA level were significantly higher in the beta group compared to the MLT and MLT + beta groups (p = 0.007). Tissue antioxidant markers (superoxide dismut ase [SOD], glutathione-peroxidase [GPx], and catalase [CAT]) were significantly lower in the C group than the S group (p < 0.05). SOD levels were simply not significant in the beta group compared to the MLT and MLT + beta groups. CAT and GPx activities were significantly higher in the beta group compared to the MLT and MLT + beta groups (p = 0.004). The histological damage ameliorated in beta, MLT and MLT + beta groups compared to C group. Conclusion. Our results suggest that melatonin and beta-glucan combination pretreatment suppressed oxidative stress and increased antioxidant levels in an experimental rat model of liver IR injuryen_US
dc.identifier.endpage627en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue5en_US
dc.identifier.pmid24285446en_US
dc.identifier.startpage621en_US
dc.identifier.urihttps://hdl.handle.net/11616/103945
dc.identifier.volume22en_US
dc.identifier.wosWOS:000328605800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectliveren_US
dc.subjectischemia reperfusion injuryen_US
dc.subjectmelatoninen_US
dc.subjectbeta-glucanen_US
dc.subjectoxidative stressen_US
dc.titleProtective Effects of Melatonin and ?-D-Glucan Against Liver Injury in Rats - a Comparative Studyen_US
dc.typeArticleen_US

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