Serum HMGB1 and Beclin 1 Levels in Patients with a Diagnosis of Schizophrenia

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dc.authorwosidUğur, Kerim/AAK-5379-2021
dc.contributor.authorYildiz, Sevler
dc.contributor.authorKilicaslan, Asli Kazgan
dc.contributor.authorEmir, Burcu Sirlier
dc.contributor.authorUgur, Kerim
dc.contributor.authorKilic, Faruk
dc.date.accessioned2024-08-04T21:01:08Z
dc.date.available2024-08-04T21:01:08Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: It is known that inflammation plays a role in the etiopathogenesis of schizophrenia. In this study, we examined high mobility group box 1 protein (HMGB1) and Beclin 1 levels and their relationship with clinical variables in patients with schizophrenia. Method: Forty-three patients with schizophrenia and 43 healthy controls were included in this study. The patients were administered sociodemographic data form, the Positive Negative Symptoms Assessment Scale (PANSS) and the Clinical Global Impressions (CGI) scale. After the scales were filled, venous blood samples were taken from both the patient and control groups to measure serum HMGB1 and Beclin 1 levels. Serum samples obtained at the end of centrifugation were measured by Enzyme -Linked ImmunoSorbent Assay (ELISA) method. Results: The mean serum HMGB1 levels were significantly increased and the mean serum Beclin 1 levels were significantly decreased in the schizophrenia group compared to the control group. In addition, a negative correlation was found between HMGB1 and Beclin 1 levels. Conclusion: In conclusion, current research shows that HMGB1 is increased and Beclin 1 is decreased in patients with schizophrenia, and these findings may contribute to the role of autophagy in the pathogenesis of schizophrenia.en_US
dc.identifier.doi10.5080/u27030
dc.identifier.issn1300-2163
dc.identifier.issue1en_US
dc.identifier.pmid38556931en_US
dc.identifier.urihttps://doi.org/10.5080/u27030
dc.identifier.urihttps://hdl.handle.net/11616/104110
dc.identifier.volume35en_US
dc.identifier.wosWOS:001211479600006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectHigh Mobility Group Box 1en_US
dc.subjectBeclin 1en_US
dc.subjectAutophagyen_US
dc.titleSerum HMGB1 and Beclin 1 Levels in Patients with a Diagnosis of Schizophreniaen_US
dc.typeArticleen_US

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