Protective effects of d-limonene and linalool on female rats intoxicated with 7,12 dimethylbenz(a)anthracene (DMBA)

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dc.authoridTANYILDIZI, SADETTIN/0000-0001-7012-5392
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridSERVI, Kadir/0000-0001-5610-9505
dc.contributor.authorTanyildizi, S.
dc.contributor.authorServi, K.
dc.contributor.authorCiftci, U.
dc.date.accessioned2024-08-04T21:00:55Z
dc.date.available2024-08-04T21:00:55Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was carried out to investigate the potential antioxidant effects of 2 monoterpenes, linalool and d-limonene, in female rats orally treated or not with dimethylbenz(a)anthracene (DMBA). For this purpose, 70 female Wistar Albino rats (7-8 weeks old) were randomly divided into 10 equal groups according to the modalities of monoterpene dietary supplementation and/or oral DMBA (65 mg/kg) treatment. Negative controls were not supplemented and untreated, positive controls received only DMBA, whereas all the other groups were fed with diets enriched by 5% limonene or linalool for 150 days and received no DMBA (groups 2 and 3) or DMBA administration 15 days after (groups 5 and 6), in the same time (groups 7 and 8) or 6 days before (groups 9 and 10) the beginning of terpene supplementation. Plasma concentrations of MDA (considered as a marker of oxidative stress) were measured in all animals on days 15, 30, 45, 60, 75 and 150. This marker was dramatically increased by DMBA treatment alone then gradually declined. By contrast, the dietary monoterpene supplementation has induced significant decreases of spontaneous MDA formation and also has markedly inhibited DMBA-induced lipid peroxidation, the best protocol being initiation of supplementation before DMBA administration. Furthermore, linalool has appeared as a more potent antioxidant than limonene. These results evidence the protective in vivo effects of monoterpenes on an experimentally induced oxidative stress and suggest that dietary supplementation would be beneficial for the prevention of free radical damage.en_US
dc.identifier.endpage225en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue5en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://hdl.handle.net/11616/103943
dc.identifier.volume160en_US
dc.identifier.wosWOS:000266684300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDimethylbenz(a)anthraceneen_US
dc.subjectmalondialdehydeen_US
dc.subjectraten_US
dc.subjectd-limoneneen_US
dc.subjectlinaloolen_US
dc.subjectdietary supplementationen_US
dc.subjectantioxidanten_US
dc.titleProtective effects of d-limonene and linalool on female rats intoxicated with 7,12 dimethylbenz(a)anthracene (DMBA)en_US
dc.typeArticleen_US

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