SYNTHESIS AND ENZYME INHIBITORY PROPERTIES OF QUINOXALINE BRIDGED BIS(IMIDAZOLIUM) SALTS

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dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridDemir, Yeliz/0000-0003-3216-1098
dc.authorwosidKoca, Murat/KGM-2351-2024
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.authorwosidDemir, Yeliz/ABI-5719-2020
dc.contributor.authorYigit, Murat
dc.contributor.authorDemir, Yeliz
dc.contributor.authorArinc, Ali
dc.contributor.authorYigit, Beyhan
dc.contributor.authorKoca, Murat
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T21:01:16Z
dc.date.available2024-08-04T21:01:16Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a series of new salts containing quinoxaline and imidazole moieties were synthesized in good yield by the reaction of 2,3 -bis(bromomethyl)quinoxalines and 1-alkylimidazoles in N,N-dimethylformamide. These salts were characterized by elemental analysis, IR, H-1 NMR and C-13 NMR spectroscopy, which support the proposed structures. Furthermore, the enzyme inhibition activities of these compounds were investigated. They showed highly potent inhibition effect on acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) (Ki values are in the range of 44.80 +/- 14.87 to 288.64 +/- 42.68 nM, 21.50 +/- 4.76 to 187.30 +/- 22.43 nM, and 5.81 +/- 0.71 to 164.52 +/- 26.0 nM for AChE, hCA I, and hCA II, respectively). Compound 3 showed the best inhibition effect for hCA I and compound 4 showed the best inhibition effect for hCA II and AChE.en_US
dc.description.sponsorshipAdiyaman University Research Fund [FEFYL/2020-0004]en_US
dc.description.sponsorshipWe thank the Adiyaman University Research Fund (FEFYL/2020-0004) for financial support of this work.en_US
dc.identifier.doi10.3987/COM-22-14668
dc.identifier.endpage1279en_US
dc.identifier.issn0385-5414
dc.identifier.issn1881-0942
dc.identifier.issue7en_US
dc.identifier.startpage1268en_US
dc.identifier.urihttps://doi.org/10.3987/COM-22-14668
dc.identifier.urihttps://hdl.handle.net/11616/104233
dc.identifier.volume104en_US
dc.identifier.wosWOS:000817759400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofHeterocyclesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPotent Carbonic-Anhydraseen_US
dc.subjectAnticholinergic Activitiesen_US
dc.subjectAlpha-Glycosidaseen_US
dc.subjectCrystal-Structureen_US
dc.subject1st Synthesisen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectDerivativesen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectAntibacterialen_US
dc.subjectBromophenolsen_US
dc.titleSYNTHESIS AND ENZYME INHIBITORY PROPERTIES OF QUINOXALINE BRIDGED BIS(IMIDAZOLIUM) SALTSen_US
dc.typeArticleen_US

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