Copeptin: A potential marker for the prediction of poor ovarian reserve in the infertile women

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dc.authoridGORKEM, Umit/0000-0002-0848-9731
dc.contributor.authorGorkem, Umit
dc.contributor.authorYildirim, Engin
dc.date.accessioned2024-08-04T20:57:33Z
dc.date.available2024-08-04T20:57:33Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: There is actually no evidence regarding the physiological effects of copeptin in infertile women with different ovarian reserve types. This study aimed to investigate the relationship of serum copeptin level with poor ovarian reserve (POR) and to reveal the predictive value of copeptin for POR development in the infertile women. Materials and Methods: All participant women were classified as the control group (n=77) included the women with diagnosis of unexplained infertility and the POR group (n=61) was composed of the women who met the European Society of Human Reproduction and Embryology consensus on POR [serum anti-Mullerian hormone (AMH) concentrations below 1.1 ng/mL]. The biochemical tests, including estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone, AMH and copeptin were analysed. The analyses of serum copeptin concentrations were measured by the means of competitive enzyme immunoassay. Results: A significant increase in the serum copeptin level existed only in the POR group. There was a significant positive correlation between serum copeptin with E2 and FSH levels in the POR group. Significant negative correlations between copeptin and AMH concentrations (r=-0.310, p=0.015) and between copeptin concentration and antral follicle counts (r=-0.284, p=0.027) were detected only in the POR group. The estimated areas under receiver operating characteristic curves for serum concentration were found to be statistically significant with a cut-off value of 3.52 (95% confidence interval 0.519-0.709), sensitivity 0.90 and specificity 0.72. Conclusion: This study confirmed that there was an elevated serum copeptin concentration in the infertile women with POR and that serum copeptin concentration may have a predictive value for POR diagnosis.en_US
dc.identifier.doi10.4274/tjod.galenos.2022.55856
dc.identifier.endpage286en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue4en_US
dc.identifier.pmid36511599en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2022.55856
dc.identifier.urihttps://hdl.handle.net/11616/102701
dc.identifier.volume19en_US
dc.identifier.wosWOS:000921197500006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCopeptinen_US
dc.subjectinfertilityen_US
dc.subjectpoor ovarian reserveen_US
dc.subjectvasopressinen_US
dc.titleCopeptin: A potential marker for the prediction of poor ovarian reserve in the infertile womenen_US
dc.typeArticleen_US

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