Oxidative stress and antioxidants in health and disease

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dc.authoridOtlu, Onder/0000-0001-5958-7609
dc.authorwosidOtlu, Onder/W-3887-2018
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorOtlu, Onder
dc.contributor.authorKarabulut, Aysun Bay
dc.date.accessioned2024-08-04T21:00:08Z
dc.date.available2024-08-04T21:00:08Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe increase in the formation of reactive oxygen and reactive nitrogen species of endogenous or exogenous origin causes oxidative stress due to pro-oxidant and antioxidant imbalance that causes cellular damage in metabolism. This can increase inflammation of cells, apoptosis and necrosis, damage to DNA base damage, DNA and protein cross-links, lipid membrane peroxidation, and mitochondrial dysfunction. Antioxidants can be described as a system that protects biomolecules and the organism against the harmful effects of free radicals, reduces or repairs the damage done by reactive oxygen species (ROS) to the target molecule, and this is called antioxidant defense. It is known that the mechanisms caused by the increase in ROS resulting from oxidative stress are positively related to the pathology of many diseases such as cancer, metabolic syndrome, atherosclerosis, malaria, Alzheimer's disease, rheumatoid arthritis, neurodegenerative diseases and preeclampsia.en_US
dc.identifier.doi10.1515/labmed-2022-0108
dc.identifier.endpage11en_US
dc.identifier.issn2567-9430
dc.identifier.issn2567-9449
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1515/labmed-2022-0108
dc.identifier.urihttps://hdl.handle.net/11616/103824
dc.identifier.volume47en_US
dc.identifier.wosWOS:001069321700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantioxidantsen_US
dc.subjectdiseasesen_US
dc.subjectfree radicalsen_US
dc.subjectnitrogen oxygen speciesen_US
dc.subjectoxidative stressen_US
dc.subjectreactive oxygen speciesen_US
dc.titleOxidative stress and antioxidants in health and diseaseen_US
dc.typeReview Articleen_US

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