CLINICAL AND PATHOLOGIC FEATURES ASSOCIATED WITH REMOVAL OF FEWER THAN 10 LYMPH NODES IN AXILLARY LYMPH NODE DISSECTION FOR BREAST CANCER

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dc.authoridKamali Polat, Ayfer/0000-0001-6414-9435;
dc.authorwosidKamali Polat, Ayfer/ADE-4664-2022
dc.authorwosidAndacoglu, Oya/S-8469-2019
dc.contributor.authorUnal, Bulent
dc.contributor.authorPolat, Ayfer Kamali
dc.contributor.authorAndacoglu, Oya
dc.contributor.authorBonaventura, Marguerite
dc.contributor.authorGur, Serhat
dc.contributor.authorSoran, Atilla
dc.date.accessioned2024-08-04T20:57:23Z
dc.date.available2024-08-04T20:57:23Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Current guidelines suggest that when performing axillary lymph node dissection for treatment of breast cancer, a minimum of 10 lymph nodes should be removed to allow for accurate pathologic staging to guide the treatment decision regarding the adjuvant treatment. The purpose of this study is to identify clinical and pathologic factors associated with retrieval of fewer than 10 lymph nodes in completion axillary lymph node dissection (CALND) performed for patients with breast cancer who had sentinel lymph node (SLN) metastasis. Materials and Methods: Patients with breast cancer who underwent SLN mapping and subsequent CALND at UPMC Magee-Womens Hospital were identified using the tumor registry database. Patients were divided into two groups according to the total number of nodes dissected. One group was comprised of patients in who had 10 or more lymph node dissection after SLN positivity while the other group comprised of the patients with fewer than 10 nodes dissected. We evaluated a number of clinical and pathological variables with their association with number of lymph nodes retrieved. These variables included patient age, timing of axillary surgery, neoadjuvant chemotherapy (NCT), tumor characteristics and SLN characteristics. Results: Three hundred seventy three patients underwent immediate or delayed completion level I-II axillary lymph node dissection after SLN biopsy demonstrated metastasis. The mean age of the patients was 53 (range 29-84) years. Fifty-four patients underwent NCT. Following SLN pathologic examination, immediate CALND was performed for 35.4% of patients and delayed CALND for 53.9% of all patients. By univariate analysis, following factors had significant association with dissection of fewer than 10 lymph nodes: NCT, tumor size, delayed CALND, and SLN micrometastases (p< 0.05). By multivariate analysis, NCT and SLN micrometastases were significantly associated with retrieval of fewer than 10 lymph nodes. Conclusion: In patients who have undergone CALND after identification of SLN metastasis, we found NCT and SLN micrometastases were associated with dissection of fewer than 10 axillary lymph nodes.en_US
dc.identifier.endpage226en_US
dc.identifier.issn2149-1976
dc.identifier.issue4en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://hdl.handle.net/11616/102592
dc.identifier.volume7en_US
dc.identifier.wosWOS:000218546500006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal of Breast Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreast canceren_US
dc.subjectsentinel nodeen_US
dc.subjectaxillary lymph node numberen_US
dc.titleCLINICAL AND PATHOLOGIC FEATURES ASSOCIATED WITH REMOVAL OF FEWER THAN 10 LYMPH NODES IN AXILLARY LYMPH NODE DISSECTION FOR BREAST CANCERen_US
dc.typeArticleen_US

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