Modulation of DMBA-induced biochemical changes by organoselenium compounds in. blood of rats

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridYılmaz, İsmet/0000-0002-7204-1050;
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.contributor.authorOzdemir, I.
dc.contributor.authorSelamoglu, Z.
dc.contributor.authorAtes, B.
dc.contributor.authorGok, Y.
dc.contributor.authorYilmaz, I.
dc.date.accessioned2024-08-04T21:00:01Z
dc.date.available2024-08-04T21:00:01Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe protective role of two synthetic organoselenium compounds 1-isopropyl-3-methylbenzimidazole-2-selenone (SeI) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (Sell) was examined against the 7,12-dimethylbenz[a]anthracene (DMBA)-induced changes in biochemical parameters in blood of rats. Albino Winstar rats (150-200 g body wt) were treated with single dose of DMBA (50 mg/kg body wt) and organoselenium compounds (25 mu mol/kg) for 4 weeks at two days internal. Blood was taken from the anaesthetized rats ventricle from their hearts for biochemical analysis. Administration of DMBA resulted in elevation of urea, uric acid and creatinine levels as well as AST, ALT and LDH activities and decrease in levels of total proteins, albumin and globulin. Set and Sell caused I significant (p<0.05) decrease ill Urea, uric acid and creatinine levels and alanine aminotransferase (ALT); aspartate aminotransferase; (AST) and lactate dehydrogenase (LDH) activities and significantly increased the levels of total protein and albumin (p<0.05). These organoselenium compounds are likely to be beneficial in human health.en_US
dc.identifier.endpage259en_US
dc.identifier.issn0301-1208
dc.identifier.issn0975-0959
dc.identifier.issue4en_US
dc.identifier.pmid17970285en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://hdl.handle.net/11616/103708
dc.identifier.volume44en_US
dc.identifier.wosWOS:000250118400010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Biochemistry & Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiochemical parametersen_US
dc.subject7,12-dimethylbenz [a]anthracene or DMBAen_US
dc.subjectoxidative stressen_US
dc.subjectorganoselenium compoundsen_US
dc.titleModulation of DMBA-induced biochemical changes by organoselenium compounds in. blood of ratsen_US
dc.typeArticleen_US

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