PROTECTIVE EFFECT OF MYRICETIN AGAINST E2-INDUCED GENOTOXIC DAMAGE IN HUMAN LYMPHOCYTES

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dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authoridKURTOĞLU, Elçin Latife/0000-0002-8375-8399
dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authorwosidASLAN, Elçin Latife/A-3923-2017
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.authorwosidKURTOĞLU, Elçin Latife/AAQ-6842-2020
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.contributor.authorYuksel, Sengul
dc.contributor.authorYesilada, Elif
dc.contributor.authorGulbay, Gonca
dc.contributor.authorKurtoglu, Elcin
dc.contributor.authorSavaci, S. Serap
dc.date.accessioned2024-08-04T21:00:55Z
dc.date.available2024-08-04T21:00:55Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractProtective effect of myricetin (MRY) against the cytotoxic and genotoxic effects of a hormonal steroid, 17 beta-estradiol (E-2), was assessed in peripheral blood human lymphocyte culture. Sister chromatid exchanges (SCE), mitotic index (MI) and replication index (RI) were scored as genetic endpoints. Firstly, the genotoxic effect of different amounts (5, 10 and 20 mu M final concentration) of E2 was tested, and 10 and 20 mu M E-2 levels were detected as genotoxic. In the second set, E-2 groups were treated with 10 mu M MRY. MRY reduced the SCE but increased MI as well as RI, suggesting its protective action on human lymphocytes in vitro against E-2-induced genotoxic damage.en_US
dc.description.sponsorshipInonu University Academic Research Project Unit [06/14]en_US
dc.description.sponsorshipThis work was supported by Inonu University Academic Research Project Unit, grant 06/14. We also thank Dr. Cemil Colak for statistical analysis.en_US
dc.identifier.endpage1026en_US
dc.identifier.issn1018-4619
dc.identifier.issue4Aen_US
dc.identifier.startpage1022en_US
dc.identifier.urihttps://hdl.handle.net/11616/103934
dc.identifier.volume21en_US
dc.identifier.wosWOS:000303697900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMyricetinen_US
dc.subjectestradiolen_US
dc.subjecthuman lymphocytesen_US
dc.subjectgenotoxicityen_US
dc.titlePROTECTIVE EFFECT OF MYRICETIN AGAINST E2-INDUCED GENOTOXIC DAMAGE IN HUMAN LYMPHOCYTESen_US
dc.typeArticleen_US

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