Can diffusion weighted magnetic resonance imaging (DW-MRI) be an alternative to 18f-FDG PET/CT (18f fluorodeoxyglucose positron emission tomography) in nasopharyngeal cancers?

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dc.authoridtemelli, oztun/0000-0003-3471-1284
dc.authorwosidEkici, Kemal/AAF-6505-2022
dc.authorwosidEkici, Kemal/AFJ-9488-2022
dc.authorwosidYıldırım, İsmail Okan/AFR-8243-2022
dc.authorwosidtemelli, Oztun/ABE-6986-2020
dc.contributor.authorYildirim, Ismail Okan
dc.contributor.authorEkici, Kemal
dc.contributor.authorDogan, Metin
dc.contributor.authorTemelli, Oztun
dc.contributor.authorKekilli, Ersoy
dc.contributor.authorSaglik, Semih
dc.contributor.authorErbay, Fatih
dc.date.accessioned2024-08-04T20:57:19Z
dc.date.available2024-08-04T20:57:19Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aimed to evaluate correlations, if any, between the ADC (Apparent Diffusion Coefficient) measurements in MRI (Magnetic Resonance Imaging) and SUV max (Standardized Uptake Value) in F-18-FDG PET/CT in patients with nasopharyngeal cancers and to investigate whether DW-MRI (Diffusion Weighted MRI) can be an alternative to F-18-FDG PET/CT in the evaluation of the response to treatment and prognosis in those patients. Methods: This study was performed between January 2015 and February 2016 at Inonu University Medical Faculty, Department of Radiology on 22 patients who were diagnosed with nasopharyngeal cancer by histopathological evaluation at Department of Pathology of the same faculty. Diffusion weighted images were obtained using 1.5 T MRI in all patients. F-18-FDG PET/CT images were obtained approximately 1-2 weeks after the diffusion-weighted images. Results: Two groups were created according to the histological subtypes as keratinized (n: 8) and non-keratinized (n: 14) among the 22 cases with a definitive histopathological diagnosis of nasopharyngeal cancer. No statistical difference was found between the groups in terms of SUVmax, SUVmean and ADC mean values (p> 0.05). ADC mean values measured in patients with nasopharyngeal cancer were statistically significantly and negatively correlated with SUV max (r=-0.619, p< 0.001) and SUV mean values (r=-0.677, p< 0.001). Conclusion: Even though there are anatomic and patient-related limitations of the DW-MRI in nasopharyngeal cancers, we suggest that it may be a complementary and alternative method of F-18-FDG PET/CT in the evaluation of treatment response and prognosis detection in nasopharyngeal cancers.en_US
dc.identifier.endpage4260en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue9en_US
dc.identifier.startpage4255en_US
dc.identifier.urihttps://hdl.handle.net/11616/102516
dc.identifier.volume28en_US
dc.identifier.wosWOS:000403460100084en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherScientific Publishers Indiaen_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNasopharyngeal Canceren_US
dc.subjectDiffusion weighted magnetic resonance imaging (DW-MRI)en_US
dc.subjectF-18-FDG PET/CTen_US
dc.titleCan diffusion weighted magnetic resonance imaging (DW-MRI) be an alternative to 18f-FDG PET/CT (18f fluorodeoxyglucose positron emission tomography) in nasopharyngeal cancers?en_US
dc.typeArticleen_US

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