Brucellosis in the etiology of febrile neutropenia: Case report

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dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.authorwosidSari, Ramazan/C-2868-2016
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorSari, R
dc.contributor.authorBuyukberber, N
dc.contributor.authorSevinc, A
dc.contributor.authorBayindir, Y
dc.contributor.authorBuyukberber, S
dc.date.accessioned2024-08-04T20:57:19Z
dc.date.available2024-08-04T20:57:19Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBrucellosis is one of the leading diseases in the differential diagnosis of fever of unknown origin in some parts of the world. It can lead to treatment failure because of slow growth in blood cultures and late appearance of signs and symptoms in patients with febrile neutropenia who were unresponsive to empirical antibiotic treatment. During the last year in our oncology unit adjuvant chemotherapy was given to 3 patients with breast (n=l) and stomach cancer (n=2) and febrile neutropenia was seen after the first course of chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracil, etoposide, Adriamycin, and cisplatin) in all 3 patients. Cefepime and amikacin were commenced but the fever continued. Prior to antifungal treatment, the patients were re-evaluated because of the history of unpasteurized milk ingestion without overt signs and symptoms. Serum agglutination tests of brucellosis were performed and were 1:640 in two patients and 1:320 in the third. Brucella melitensis was identified only in one case although multiple blood cultures were taken from all 3 patients. Empiric antibiotic treatment was stopped and streptomycin 1 g/day (10 days), doxycycline 200 mg/day (28 days), trimethoprim 320 mg and sulfamethoxazole 1600 mg/day (28 days) were given. Although neutropenia continued, fever subsided in 3 days. Due to high incidence of brucellosis in some geographic areas, especially in the Middle East, brucellosis should be kept in mind in the differential diagnosis of febrile neutropenia.en_US
dc.identifier.endpage91en_US
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.issue1en_US
dc.identifier.pmid11892906en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://hdl.handle.net/11616/102507
dc.identifier.volume14en_US
dc.identifier.wosWOS:000174169700014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbrucellosisen_US
dc.subjectfebrile neutropeniaen_US
dc.subjectetiologyen_US
dc.titleBrucellosis in the etiology of febrile neutropenia: Case reporten_US
dc.typeArticleen_US

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