Xanthogranulomatous appendicitis: A comprehensive literature review

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridÖzcan, Mehmet/0000-0003-0969-1373
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridTuncer, Adem/0000-0001-5381-513X
dc.authoridSahin, Emrah/0000-0001-5267-9068
dc.authoridDemyati, Khaled/0000-0002-9591-2664
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidÖzcan, Mehmet/A-1160-2019
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidKoc, Cemalettin/B-6430-2018
dc.authorwosidSahin, Emrah/B-8806-2019
dc.contributor.authorAkbulut, Sami
dc.contributor.authorDemyati, Khaled
dc.contributor.authorKoc, Cemalettin
dc.contributor.authorTuncer, Adem
dc.contributor.authorSahin, Emrah
dc.contributor.authorOzcan, Mehmet
dc.contributor.authorSamdanci, Emine
dc.date.accessioned2024-08-04T21:02:24Z
dc.date.available2024-08-04T21:02:24Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND Xanthogranulomatous inflammation is characterized histologically by a collection of lipid-laden macrophages admixed with lymphocytes, plasma cells, neutrophils, and often multinucleated giant cells with or without cholesterol clefts. AIM To review the medical literature on xanthogranulomatous appendicitis (XGA). METHODS We present a patient with XGA and review published articles on XGA accessed via the PubMed, MEDLINE, Google Scholar, and Google databases. Keywords used were appendix vermiformis, appendectomy, acute appendicitis, and XGA. The search included articles published before May 2020, and the publication language was not restricted. The search included letters to the editor, case reports, review articles, original articles, and meeting presentations. Articles or abstracts containing adequate information about age, sex, clinical presentation, white blood cells, initial diagnosis, surgical approach, histopathological and immunohistochemical features of appendectomy specimens were included in the study. RESULTS A total of 29 articles involving 38 patients with XGA, were retrospectively analyzed. Twenty (52.6%) of the 38 patients, aged 3 to 78 years (median: 34; IQR: 31) were female, and the remaining 18 (47.4%) were male. Twenty-five patients were diagnosed with acute appendicitis, ruptured appendicitis, or subacute appendicitis, and the remaining 13 patients underwent surgery for tumoral lesions of the ileocecal region. Twenty-two of the patients underwent urgent or semi-urgent surgery, and the remaining 16 patients underwent interval appendectomy. CONCLUSION Xanthogranulomatous inflammation rarely affects the appendix vermiformis. It is associated with significant diagnostic and therapeutic dilemmas due to its variable presentation. It is often associated with interval appendectomies, and a significant number of patients require bowel resection due to the common presentation of a tumoral lesion. XGA is usually identified retrospectively on surgical pathology and has no unique features in preoperative diagnostic studies.en_US
dc.identifier.doi10.4240/wjgs.v13.i1.76
dc.identifier.endpage86en_US
dc.identifier.issn1948-9366
dc.identifier.issue1en_US
dc.identifier.pmid33552395en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.4240/wjgs.v13.i1.76
dc.identifier.urihttps://hdl.handle.net/11616/104725
dc.identifier.volume13en_US
dc.identifier.wosWOS:000613376900006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Gastrointestinal Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAppendix vermiformisen_US
dc.subjectAcute appendicitisen_US
dc.subjectAppendectomyen_US
dc.subjectInterval appendectomyen_US
dc.subjectXanthogranulomatous inflammationen_US
dc.subjectCD68 antibody stainingen_US
dc.titleXanthogranulomatous appendicitis: A comprehensive literature reviewen_US
dc.typeArticleen_US

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