Good response to HBsAg vaccine in dialysis patients is associated with high CD4+/CD8+ ratio

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dc.authoridtaskapan, hulya/0000-0001-8736-4779;
dc.authorwosidtaskapan, hulya/ABI-7737-2020
dc.authorwosidSari, Funda/C-7068-2016
dc.contributor.authorSari, Funda
dc.contributor.authorTaskapan, Hulya
dc.date.accessioned2024-08-04T20:58:54Z
dc.date.available2024-08-04T20:58:54Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractChronic renal failure is accompanied by various abnormalities of innate and acquired, cellular and humoral immunity. We aimed to investigate whether positive Candida skin test results, CD4+ and CD8+, before the first dose of vaccination could be a predictor for antibody response to hepatitis B vaccination and the relation of these parameters with hepatitis B antibody levels 1 month after the last dose of vaccination. The present study was carried out in 57 dialysis patients. All patients received recombinant hepatitis B vaccine (40 mu g) given intramuscularly in the deltoid muscle in a four-dose schedule at 0, 1, 2, and 6 months. Candida skin test and lymphocyte subsets (CD4+ and CD8+) were determined before the first dose of vaccination and 1 month after the fourth inoculation of hepatitis B vaccine. Ten patients (17.5%) were non-responders (HBsAb < 10 IU/L), while 47 patients (82.5%) were responders (HBsAb a parts per thousand yen 10 IU/L). However, 29 patients (50.9%) were weak responders (HBsAb:10-100 IU/L), 18 patients (31.6%) good responders (HBsAb > 100 IU/L), which was determined 1 month after the fourth dose of vaccination. Thirty-nine patients (68.4%) and 44 patients (77.2%) were anergic to Candida skin test before the first dose and 1 month after fourth inoculation of hepatitis B vaccine, respectively. There was no relationship between Candida skin test and response to hepatitis B vaccination. Mean age was lower, and CD4+/CD8+ ratio measured both before and after vaccination was higher in good responders compared with that of weak responders and that of non-responders. Females were better responders than males. High skin test anergy rate and low seroconversion rate after hepatitis B vaccination are important problems in patients on dialysis. Females, younger patients, and patients with higher CD4+/CD8+ ratio have better HBsAb antibody response to hepatitis B vaccination.en_US
dc.identifier.doi10.1007/s11255-011-0043-6
dc.identifier.endpage1506en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue5en_US
dc.identifier.pmid21809071en_US
dc.identifier.startpage1501en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-011-0043-6
dc.identifier.urihttps://hdl.handle.net/11616/103271
dc.identifier.volume44en_US
dc.identifier.wosWOS:000308957400031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic renal failureen_US
dc.subjectHepatitis B vaccinationen_US
dc.subjectCandida skin testen_US
dc.subjectCD4+en_US
dc.subjectCD8+en_US
dc.titleGood response to HBsAg vaccine in dialysis patients is associated with high CD4+/CD8+ ratioen_US
dc.typeArticleen_US

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