Investigation of the Effect of Astaxanthin on Autophagy in Renal Ischemia-reper fusion Modeled Rats

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dc.contributor.authorKisaoglu, Aysegul
dc.contributor.authorKose, Evren
dc.contributor.authorYilmaz, Nesibe
dc.contributor.authorTanbek, Kevser
dc.contributor.authorYildiz, Azibe
dc.contributor.authorYilmaz, Umit
dc.contributor.authorCirik, Rumeyza Hilal
dc.date.accessioned2026-04-04T13:30:50Z
dc.date.available2026-04-04T13:30:50Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective: The aim of this study was to investigate the effect of various astaxanthin (ATX) doses on oxidative damage and autophagy in renal ischemia-reperfusion (I/R) injury-modeled rats. Methods: The rats were divided into five groups: sham group (n=8), I/R (n=8), I/R + 5 mg/kg ATX (n=8), I/R + 10 mg/kg ATX (n=8), and I/R + 25 mg/ kg ATX (n=8) groups. ATX was dissolved in 5 mg/kg, 10 mg/kg, and 25 mg/ kg olive oil for 7 days and administered to the rats in the experimental group. Sham and I/R groups were also administered ATX solution (olive oil) via oral gavage for 7 days. Renal ischemia reperfusion was induced in all rats except the sham group after the last dose was administered on the 7 th day. Reperfusion was conducted for 24 hours after 45 minutes of ischemia. Results: Blood samples were collected, and kidney tissue were incised for biochemical and histological analyses. Superoxide dismutase (SOD) and total antioxidant status (TAS) were significantly lower in the I/R group than in the sham group (p<0.05), whereas malondialdehyde (MDA) and total oxidant status (TOS) values were higher (p<0.05). It was determined that SOD and TAS increased and MDA and TOS decreased in the ATXadministration groups compared with the I/R group, independent of the dose (p<0.05). In the 25 mg/kg ATX + I/R group, Beclin-1 and LC3 0 immunoreactivities were significantly higher than those in the other groups (p<0.05). The lowest p62 immunoreactivity was observed in the 25 mg/kg ATX + I/R group. Conclusions: ATX had a protective effect on kidney function and against oxidative damage. Furthermore, high-dose ATX administration protected kidney tissue via autophagy induction in this study.
dc.description.sponsorshipResearch Fund of Inonu University [TYL-2020-2009]
dc.description.sponsorshipThis study was supported by the Research Fund of Inonu University, Project No: TYL-2020-2009.
dc.identifier.doi10.4274/MMJ.galenos.2024.27243
dc.identifier.endpage108
dc.identifier.issn2149-2042
dc.identifier.issn2149-4606
dc.identifier.issue2
dc.identifier.orcid0000-0002-5527-8507
dc.identifier.orcid0000-0003-0248-3483
dc.identifier.orcid0000-0003-4144-9747
dc.identifier.pmid38940481
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.4274/MMJ.galenos.2024.27243
dc.identifier.urihttps://hdl.handle.net/11616/108395
dc.identifier.volume39
dc.identifier.wosWOS:001274111400004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofMedeniyet Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAstaxanthin
dc.subjectrenal
dc.subjectischemia/reperfusion
dc.subjectoxidative stress
dc.subjectautophagy
dc.titleInvestigation of the Effect of Astaxanthin on Autophagy in Renal Ischemia-reper fusion Modeled Rats
dc.typeArticle

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