Early and late state subacute sclerosing panencephalitis chemical shift imaging and single voxel MR spectroscopy
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AJNR
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Subacute sclerosing panencephalitis (SSPE) is a rare,
progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic
abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess
areas of involvement in the early stages when MR imaging findings were normal.
METHODS: Children with stage II (n 3) or III (n 3) SSPE and 10 healthy, age-matched
children underwent MR imaging, multivoxel MR spectroscopy, and short-echo single-voxel MR
spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift
imaging. For SVS, 2 2 2-cm voxels were placed in the frontal subcortical white matter
(FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr),
choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated.
RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients
and control subjects showed significant differences in FSWM and POWM (P < .01). In patients
with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P < .01).
NAA/Cr ratios in patients with stage II SSPE and those in the control group were not
significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr,
increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in
patients with stage III SSPE.
CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and
findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR
spectroscopy could be a promising technique for early diagnosis and treatment planning in
cases of SSPE.
Açıklama
Anahtar Kelimeler
Kaynak
AJNR
WoS Q Değeri
Scopus Q Değeri
Cilt
24
Sayı
Künye
Alkan, A. Saraç, K. Kutlu, R. Yakıncı, M. C. Sığırcı, A. Aslan, M. Baysal, T. (2003). Early and late state subacute sclerosing panencephalitis chemical shift imaging and single voxel MR spectroscopy. AJNR. 24:501–506.
