Outcome of split liver transplantation vs living donor liver transplantation: A systematic review and meta-analysis

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridAksoy, Fuat/0000-0001-5808-9384
dc.authoridGARZALI, IBRAHIM UMAR/0000-0002-9797-851X
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidAksoy, Fuat/HII-8895-2022
dc.authorwosidGARZALI, IBRAHIM UMAR/ITU-1475-2023
dc.contributor.authorGarzali, Ibrahim Umar
dc.contributor.authorAkbulut, Sami
dc.contributor.authorAloun, Ali
dc.contributor.authorNaffa, Motaz
dc.contributor.authorAksoy, Fuat
dc.date.accessioned2024-08-04T21:00:08Z
dc.date.available2024-08-04T21:00:08Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUNDThe outcomes of liver transplantation (LT) from different grafts have been studied individually and in combination, but the reports were conflicting with some researchers finding no difference in both short-term and long-term outcomes between the deceased donor split LT (DD-SLT) and living donor LT (LDLT).AIMTo compare the outcomes of DD-SLT and LDLT we performed this systematic review and meta-analysis.METHODSThis systematic review was performed in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The following databases were searched for articles comparing outcomes of DD-SLT and LDLT: PubMed; Google Scholar; Embase; Cochrane Central Register of Controlled Trials; the Cochrane Database of Systematic Reviews; and Reference Citation Analysis (https://www.referencecitationanalysis.com/). The search terms used were: liver transplantation; liver transplant; split liver transplant; living donor liver transplant; partial liver transplant; partial liver graft; ex vivo splitting; and in vivo splitting.RESULTSTen studies were included for the data synthesis and meta-analysis. There were a total of 4836 patients. The overall survival rate at 1 year, 3 years and 5 years was superior in patients that received LDLT compared to DD-SLT. At 1 year, the hazard ratios was 1.44 (95% confidence interval: 1.16-1.78; P = 0.001). The graft survival rate at 3 years and 5 years was superior in the LDLT group (3 year hazard ratio: 1.28; 95% confidence interval: 1.01-1.63; P = 0.04).CONCLUSIONThis meta-analysis showed that LDLT has better graft survival and overall survival when compared to DD-SLT.en_US
dc.identifier.doi10.4240/wjgs.v15.i7.1522
dc.identifier.endpage1531en_US
dc.identifier.issn1948-9366
dc.identifier.issue7en_US
dc.identifier.pmid37555109en_US
dc.identifier.startpage1522en_US
dc.identifier.urihttps://doi.org/10.4240/wjgs.v15.i7.1522
dc.identifier.urihttps://hdl.handle.net/11616/103817
dc.identifier.volume15en_US
dc.identifier.wosWOS:001046814000025en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Gastrointestinal Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeceased donor liver transplantationen_US
dc.subjectLiving donor liver transplantationen_US
dc.subjectSplit liver transplantationen_US
dc.subjectOverall survivalen_US
dc.subjectGraft survivalen_US
dc.subjectAcute rejectionen_US
dc.titleOutcome of split liver transplantation vs living donor liver transplantation: A systematic review and meta-analysisen_US
dc.typeReview Articleen_US

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