Electrochemical and in Silico Investigations of the Interaction between Nitro Blue Tetrazolium Chloride and Bovine Serum Albumin

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dc.authoridKuyumcu Savan, Ebru/0000-0002-8851-0907
dc.authoridalagoz, mehmet abdullah/0000-0001-5190-7196
dc.authoridKAZICI, Dilek/0000-0002-0437-5905
dc.authorwosidKuyumcu Savan, Ebru/E-3430-2019
dc.authorwosidalagoz, mehmet abdullah/W-7847-2018
dc.contributor.authorKazici, Dilek
dc.contributor.authorAlagoz, Mehmet Abdullah
dc.contributor.authorSavan, Ebru Kuyumcu
dc.date.accessioned2024-08-04T20:58:38Z
dc.date.available2024-08-04T20:58:38Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe binding ability of the drug on its interaction with the protein will also significantly affect the apparent volume of distribution of the drugs and, in many cases the rate of elimination of the drugs. The interactions of proteins and other molecules are a fascinating topic applied to surface technologies and sensors. Therefore, it is aimed to determine the NBTCand to elucidate its interaction with Bovine Serum Albumin (BSA) by electrochemical and in silico studies in this paper. The reduction in BSA oxidation signals measured by differential pulse voltammetry upon incubation with different NBTC concentrations indicated that NBTC was bound to BSA. In addition, in silico (molecular modeling and molecular dynamics) studies have been conducted on the interactions of NBTC with proteins in plasma. As a result of the in silico studies investigated the interactions of NBTC with serum albumin, its binding affinity, and the dynamic process in the binding state. In silico studies showed that NBTC binds to BSA with high affinity (with-7.986 kcal/mol docking score), and this binding was stable (with a 3.0 average RMSD value). Eventually, the results of the electrochemical and modeling studies were perfectly matched.en_US
dc.identifier.doi10.37819/nanofab.007.225
dc.identifier.endpage21en_US
dc.identifier.issn2299-680X
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.37819/nanofab.007.225
dc.identifier.urihttps://hdl.handle.net/11616/103037
dc.identifier.volume7en_US
dc.identifier.wosWOS:000919670600005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEurasia Acad Publ Group (Eapg)en_US
dc.relation.ispartofNanofabricationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitro Blue Tetrazolium Chlorideen_US
dc.subjectBovine Serum Albuminen_US
dc.subjectin Silicoen_US
dc.subjectVoltammetryen_US
dc.titleElectrochemical and in Silico Investigations of the Interaction between Nitro Blue Tetrazolium Chloride and Bovine Serum Albuminen_US
dc.typeArticleen_US

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