Living donor liver transplantation for acute liver failure in pediatric patients caused by the ingestion of fireworks containing yellow phosphorus
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Liver Transplantation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Yellow phosphorus is a protoplasmic toxicant that targets the liver. The ingestion of fireworks containing yellow phosphorus,
either by children who accidentally consume them or by adults who are attempting suicide, often results in death due to
acute liver failure (ALF). We present the outcomes of 10 children who ingested fireworks containing yellow phosphorus.
There were 6 boys and 4 girls, and their ages ranged from 21 to 60 months. One patient remained stable without liver complications
and was discharged. Three patients died of hepatorenal failure and cardiovascular collapse, and living donor liver
transplantation (LDLT) was performed for 6 patients. The patients had grade II or III encephalopathy, a mean alanine aminotransferase
level of 1148.2 IU/L, a mean aspartate aminotransferase level of 1437.5 IU/L, a mean total bilirubin level of 6.9
mg/dL, a mean international normalized ratio of 6.6, a mean Pediatric End-Stage Liver Disease score of 33.7, and a mean
Child-Pugh score of 11.3. Postoperatively, 2 patients had persistent encephalopathy and died on the second or third postoperative
day, and 1 patient died of cardiac arrest on the first postoperative day despite a well-functioning graft. The other 3
patients were still alive at a mean of 204 days. In conclusion, the ingestion of fireworks containing yellow phosphorus
causes ALF with a high mortality rate. When signs of irreversible ALF are detected, emergency LDLT should be considered
as a lifesaving procedure; however, if yellow phosphorus toxicity affects both the brain and the heart in addition to the liver,
the mortality rate remains very high despite liver transplantation.
Açıklama
Anahtar Kelimeler
Kaynak
Liver Transplantation
WoS Q Değeri
Scopus Q Değeri
Cilt
17
Sayı
11
Künye
Ateş, M. Dirican, A. Özgör, D. Aydın, C. Işık, B. Ara, C. Yılmaz, M. Selimoğlu, M. A. Kayaalp, C. Yılmaz, S. (2011). Living donor liver transplantation for acute liver failure in pediatric patients caused by the ingestion of fireworks containing yellow phosphorus. Liver Transplantation, 17(11), 1286–1291.
