A NOVEL SCHIFF BASE DERIVATIVE FOR EFFECTIVE TREATMENT OF AZOXYMETHANE INDUCED COLON CANCER

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dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridDede, Bülent/0000-0003-1416-7373
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridTelci, Dilek/0000-0002-2793-6533
dc.authoridDoğan, Ayşegül/0000-0003-4160-2270;
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidDemirci, Selami/AAC-9963-2020
dc.authorwosidDede, Bülent/HIZ-5767-2022
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidTelci, Dilek/N-5053-2019
dc.authorwosidDoğan, Ayşegül/AAD-3223-2019
dc.authorwosidTUZCU, MEHMET/H-2953-2018
dc.contributor.authorDogan, Aysegul
dc.contributor.authorBasak, Nese
dc.contributor.authorDemirci, Selami
dc.contributor.authorTelci, Dilek
dc.contributor.authorDede, Bulent
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorOzercan, Ibrahim Halil
dc.date.accessioned2024-08-04T20:56:20Z
dc.date.available2024-08-04T20:56:20Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe field of cancer research has been emerged in recent years for the development of specific drugs to cancer treatment. New agents with the ability to provide efficient treatment by reducing side effects has led to new opportunities for improving agents for cytotoxic therapies. While there are several drugs for colon cancer treatment, researchers are trying to evaluate new agents or combinations of existing ones which can be used efficiently. Schiff bases with a wide range of variety and biological properties including anticancer activity might be used for colon cancer treatment. In the current study, a novel schiff base derivative synthesized by our group was tested in vivo for colon cancer. In a model of azoxymethane (AOM) induced colorectal cancer, chemopreventive properties of schiff base was also analyzed in rats. While AOM induced de novo crypt formation, adenocarcinoma and dysplasia development, schiff base application reduced the number of aberrant crypt foci (ACF), dysplasia or adenocarcinoma. Analysis of the intestinal mucosa showed that peritoneal administration of SB complex not only decreased the protein expression of COX-2, Bcl-2 and NF-kappa B but also enhanced the Bax expression suggesting the apoptotic and anti-proliferative effects for this compound. Our findings showed that SB complex might be used for the colorectal cancer treatment. Further studies are highly warranted to obtain additional insights and identify mode of action for the schiff base.en_US
dc.description.sponsorshipTurkish Academy of Science, Ankara (TUBA)en_US
dc.description.sponsorshipThis work was partially supported by grants from Turkish Academy of Science, Ankara (TUBA) (K.S.).en_US
dc.identifier.doi10.13040/IJPSR.0975-8232.5(8).3544-50
dc.identifier.endpage3550en_US
dc.identifier.issn0975-8232
dc.identifier.issue8en_US
dc.identifier.startpage3544en_US
dc.identifier.urihttps://doi.org/10.13040/IJPSR.0975-8232.5(8).3544-50
dc.identifier.urihttps://hdl.handle.net/11616/102219
dc.identifier.volume5en_US
dc.identifier.wosWOS:000215490600061en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherInt Journal Pharmaceutical Sciences & Researchen_US
dc.relation.ispartofInternational Journal of Pharmaceutical Sciences and Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchiff baseen_US
dc.subjectcolon canceren_US
dc.subjectazoxymethaneen_US
dc.subjectaberrant crypt focien_US
dc.titleA NOVEL SCHIFF BASE DERIVATIVE FOR EFFECTIVE TREATMENT OF AZOXYMETHANE INDUCED COLON CANCERen_US
dc.typeArticleen_US

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