Can myocardial dysfunction be detected in patients with rheumatoid arthritis with no cardiac symptoms?

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dc.contributor.authorAkgol, G.
dc.contributor.authorGulkesen, A.
dc.contributor.authorUslu, E. Y.
dc.contributor.authorAlkan, G.
dc.contributor.authorBolayir, H. A.
dc.contributor.authorGelen, M. A.
dc.contributor.authorUslu, M. F.
dc.date.accessioned2024-08-04T20:57:19Z
dc.date.available2024-08-04T20:57:19Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of our study was to investigate the role of tissue Dop-pler and Myocardial Performance Index (MPI) in evaluating cardiac involvement in patients with rheumatoid arthritis (RA) with no cardi-ac symptoms, to determine whether these mea-surements differ between healthy controls and RA patients, and whether they can be used to determine the risk of cardiovascular disease and predict prognosis.PATIENTS AND METHODS: 50 RA patients fulfilling the 2010 American College of Rheuma-tology/European League Against Rheumatism (ACR/EULAR) RA criteria and 50 healthy volun-teering controls were included in the study. All patients and controls were assessed using elec-trocardiography (ECG), echocardiography, con-ventional Doppler echocardiography and tissue Doppler echocardiography. MPI values were cal-culated. In addition, RA patients were compared after being divided into two subgroups: sero-positive and seronegative RA. Disease activi-ty levels of the patients were determined based on Disease Activity Score in 28 Joints (DAS28).RESULTS: The control group and RA group were compared in terms of PR interval, left atrial diameter, E/A, E/e', and MPI values. Comparisons between the groups yielded statistically signifi-cant differences in left atrial diameter, E/A, E/e', and MPI values and no significant difference in PR intervals. These parameters were also com-pared between seropositive and seronegative pa-tients. Left atrial diameter was significantly high-er in seronegative patients than in seropositive patients. There was no significant difference in the other values. DAS28 scores had no correla-tion with cardiac parameters.CONCLUSIONS: Early detection of ventricu-lar dysfunction in RA may be useful in clinical practice when predicting prognosis and optimiz-ing treatment. The present study found that RA patients had impaired tissue Doppler measure-ments and MPI results compared to controls. MPI and tissue Doppler may be useful in early detection of ventricular dysfunction.en_US
dc.identifier.endpage4405en_US
dc.identifier.issn1128-3602
dc.identifier.issue10en_US
dc.identifier.pmid37259720en_US
dc.identifier.startpage4399en_US
dc.identifier.urihttps://hdl.handle.net/11616/102518
dc.identifier.volume27en_US
dc.identifier.wosWOS:001021187100010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectMyocardial performance in-dex (MPI)en_US
dc.subjectTissue doppleren_US
dc.titleCan myocardial dysfunction be detected in patients with rheumatoid arthritis with no cardiac symptoms?en_US
dc.typeArticleen_US

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