Primary Drug Resistance and Molecular Epidemiology of the Mycobacterium tuberculosis Strains Isolated in the Kelkit Valley

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dc.authoridOTLU, BARIS/0000-0002-6220-0521;
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidYilmaz, Ayse/KHD-3413-2024
dc.authorwosidCelikel, Serhat/IWV-3482-2023
dc.contributor.authorBulut, Yunus
dc.contributor.authorYenisehirli, Guelguen
dc.contributor.authorOtlu, Baris
dc.contributor.authorSeyfikli, Zehra
dc.contributor.authorCelikel, Serhat
dc.contributor.authorYilmaz, Ayse
dc.contributor.authorInonu, Handan
dc.date.accessioned2024-08-04T21:00:54Z
dc.date.available2024-08-04T21:00:54Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of this study was to determine the primary drug resistance rates and genotypes of resistant Mycobacterium tuberculosis strains isolated in the Kelkit Valley. Materials and Methods: Primary resistance to isoniazid (INH). rifampicin (RIF), ethambutol (ETB), and streptomycin (SM) was determined with the BACTEC 460 radiometric system. Forty-eight resistant M. tuberculosis strains isolated from tuberculosis patients living in the Kelkit Valley were genotyped using the spoligotyping method. Results: Approximately 11.6% of the strains were resistant against at least one major drug, and 8.3% were resistant against more than one drug. Single-drug resistance for INH. ETB, SM. and RIF was found as 5.8%, 2.1%, 3.7%, and 0.0%, respectively. Two or more drug resistance rates for SM + ETB, SM + INH, INH + RIF, RIF + ETB, INH + ETB + RIF, SM + ETB + INH and INH + ETB + RIF + SM were determined as 0.8%, 1.7%, 0.4%, 0.8%. 2.9%. 0.4%, and 1.2%, respectively. Fifteen spoligotype groups were created when the results were compared with the world databank (SpolDB4). Families of four strains could not be determined. The spoligotype groups most frequently encountered in our study were ST4 (n = 10, 20.8%). ST53 (n = 6, 12.5%). ST7 (n = 4, 8.3%), ST41 (n = 4, 8.3%) and ST31 (n = 4, 8.3%), and the most frequently encountered families were T1 (n = 18, 37.5%), S (n = 12, 25%) and LAM-7 TUR (n = 4, 8.3%). Conclusions: High rates of primary resistance against major anti-tuberculosis drugs, the LAM-7 TUR clone, and high grouping rates were detected in this study. the first such study carried out in the Kelkit Valley.en_US
dc.identifier.doi10.3906/sag-0710-11
dc.identifier.endpage107en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.3906/sag-0710-11
dc.identifier.urihttps://hdl.handle.net/11616/103911
dc.identifier.volume39en_US
dc.identifier.wosWOS:000264805800018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectM. tuberculosisen_US
dc.subjectprimary drug resistanceen_US
dc.subjectmolecular epidemiologyen_US
dc.titlePrimary Drug Resistance and Molecular Epidemiology of the Mycobacterium tuberculosis Strains Isolated in the Kelkit Valleyen_US
dc.typeArticleen_US

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