Synthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman's Syndrome) after Surgical Injury

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dc.contributor.authorErden, Busra Aksoy
dc.contributor.authorKurus, Meltem
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorAtes, Burhan
dc.date.accessioned2026-04-04T13:34:43Z
dc.date.available2026-04-04T13:34:43Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractAsherman's syndrome, which can occur during the regeneration of damaged uterine tissue after surgical interventions, is a significant health problem in women. This study aimed to acquire and characterize cyclodextrin-based hydrogels, which can be used to prevent Asherman's syndrome, and investigate their effectiveness with biomedical applications. A series of hydrogels were synthesized from the cross-linking of beta-cyclodextrin and different polyphenols with epoxy-functional PEG. Their chemical, physical, and biological properties were subsequently determined. The results demonstrated that the cyclodextrin-based hydrogels had a porous structure, high swelling ratio, good injectability, drug release ability, and antioxidant activity. Cell culture results illustrated that the hydrogels had no significant cytotoxicity toward L929 fibroblast cells. Considering all properties, the beta-CD-PEG-600-Ec hydrogel showed the most satisfactory properties rather than other ones. The potential of this hydrogel in preventing Asherman's syndrome was evaluated in a rat model. The results revealed that the beta-estradiol- and melatonin-loaded cyclodextrin-based multifunctional hydrogel group both structurally and mechanically showed an antiadhesion effect in the uterus and a therapeutic effect on the damage with the beta-estradiol and melatonin that it contains compared to the Asherman (ASH) group. This double drug-loaded hydrogel can be a promising candidate for preventing Asherman's syndrome due to its versatile properties.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [215Z322]
dc.description.sponsorshipThis work was supported financially by the Scientific and Technological Research Council of Turkey (TUBITAK) [Project no. 215Z322].
dc.identifier.doi10.1021/acsomega.4c03655
dc.identifier.endpage31973
dc.identifier.issn2470-1343
dc.identifier.issue29
dc.identifier.orcid0000-0002-7910-4595
dc.identifier.orcid0000-0001-7113-6691
dc.identifier.orcid0000-0002-4788-278X
dc.identifier.orcid0000-0003-0724-4772
dc.identifier.orcid0000-0001-6080-229X
dc.identifier.pmid39072112
dc.identifier.startpage31957
dc.identifier.urihttps://doi.org/10.1021/acsomega.4c03655
dc.identifier.urihttps://hdl.handle.net/11616/109365
dc.identifier.volume9
dc.identifier.wosWOS:001279950200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Omega
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectMesenchymal Stem-Cells
dc.subjectThermosensitive Hydrogel
dc.subjectHysteroscopic Surgery
dc.subjectGamma-Cyclodextrin
dc.subjectDrug-Delivery
dc.subjectIn-Vitro
dc.subjectPeg
dc.subjectGel
dc.subjectScaffold
dc.subjectMicrospheres
dc.titleSynthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman's Syndrome) after Surgical Injury
dc.typeArticle

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